Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.
Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Nutrients. 2020 Nov 28;12(12):3665. doi: 10.3390/nu12123665.
The prevalence and incidence of Parkinson's disease (PD), an age-related neurodegenerative disease, are higher among elderly people. Independent of etiology, dysfunction and loss of dopaminergic neurons are common pathophysiological changes in PD patients with impaired motor and non-motor function. Currently, preventive or therapeutic treatment for combating PD is limited. The ghrelin axis and ghrelin receptor have been implicated in the preservation of dopaminergic neurons and have potential implications in PD treatment. Teaghrelin, a compound originating from Chin-Shin Oolong tea, exhibits ghrelin agonist activity. In this study, the neuroprotective potential of teaghrelin against PD was explored in a cell model in which human neuroblastoma SH-SY5Y cells were treated with the mitochondrial toxin 1-methyl-4-phenylpyridinium (MPP). Upon MPP exposure, SH-SY5Y cells exhibited decreased mitochondrial complex I activity and apoptotic cell death. Teaghrelin activated AMP-activated protein kinase (AMPK)/sirtuin 1(SIRT1)/peroxisome proliferator-activated receptor gamma (PPARγ) coactivator-1α (PGC-1α) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathways to antagonize MPP-induced cell death. Herein, we propose that teaghrelin is a potential candidate for the therapeutic treatment of PD.
帕金森病（PD）是一种与年龄相关的神经退行性疾病，其患病率和发病率在老年人中较高。无论病因如何，功能障碍和多巴胺能神经元的丧失都是 PD 患者运动和非运动功能受损的常见病理生理变化。目前，针对 PD 的预防或治疗手段有限。胃饥饿素轴和胃饥饿素受体被认为与多巴胺能神经元的保护有关，并可能对 PD 的治疗有影响。茶褐素是一种源自 Chin-Shin 乌龙茶的化合物，具有胃饥饿素激动剂活性。在这项研究中，用线粒体毒素 1-甲基-4-苯基吡啶（MPP）处理人神经母细胞瘤 SH-SY5Y 细胞，以探讨茶褐素对 PD 的神经保护潜力。在 MPP 暴露后，SH-SY5Y 细胞的线粒体复合物 I 活性降低，发生凋亡性细胞死亡。茶褐素通过激活 AMP 激活的蛋白激酶（AMPK）/沉默调节蛋白 1（SIRT1）/过氧化物酶体增殖物激活受体γ（PPARγ）共激活因子 1α（PGC-1α）和细胞外信号调节激酶 1 和 2（ERK1/2）通路拮抗 MPP 诱导的细胞死亡。在此，我们提出茶褐素是 PD 治疗的潜在候选药物。
