Maitre Yoann, Micheneau Pierre, Delpierre Alexis, Mahalli Rachid, Guerin Marie, Amador Gilles, Denis Frederic
Emergency Department, Montpellier University Hospital, 34259 Montpellier, France.
EA 2415, Aide à la Décision pour une Médecine Personnalisée, Université de Montpellier, 34090 Montpellier, France.
J Clin Med. 2020 Nov 28;9(12):3876. doi: 10.3390/jcm9123876.
This systematic review aims to investigate the role of the oral microbiome in the pathophysiology of mental health disorders and to appraise the methodological quality of research of the oral-brain axis which is a growing interest area. The PRISMA guideline was adopted, to carry out an electronic search through the MEDLINE database, to identify studies that have explored the role of the oral microbiome in the pathophysiology of mental health disorders published from 2000 up to June 2020. The search resulted in 140 records; after exclusions, a total of 22 papers were included in the present review. In accordance with the role of the oral microbiome in the pathophysiology of mental disorders, four mental disorders were identified: Alzheimer's disease, dementia, and cognitive disorders; autism spectrum disorder; Down's syndrome and mental retardation; and Bipolar disorders. Studies argue for correlations between oral microbiota and Alzheimer's disease, autism spectrum disorders, Down's syndrome, and bipolar disorders. This field is still under-studied, and studies are needed to clarify the biological links and interconnections between the oral microbiota and the pathophysiology of all mental health disorders. Researchers should focus their efforts to develop research on the oral-brain axis in the future.
本系统评价旨在研究口腔微生物群在精神健康障碍病理生理学中的作用，并评估口腔-脑轴这一日益受关注领域的研究方法学质量。采用PRISMA指南，通过MEDLINE数据库进行电子检索，以识别2000年至2020年6月发表的探讨口腔微生物群在精神健康障碍病理生理学中作用的研究。检索结果有140条记录；排除后，本综述共纳入22篇论文。根据口腔微生物群在精神障碍病理生理学中的作用，确定了四种精神障碍：阿尔茨海默病、痴呆和认知障碍；自闭症谱系障碍；唐氏综合征和智力障碍；以及双相情感障碍。研究表明口腔微生物群与阿尔茨海默病、自闭症谱系障碍、唐氏综合征和双相情感障碍之间存在相关性。该领域仍研究不足，需要开展研究以阐明口腔微生物群与所有精神健康障碍病理生理学之间的生物学联系和相互关系。研究人员未来应集中精力开展口腔-脑轴方面的研究。
