Emergency Department, Montpellier University Hospital, 34090 Montpellier, France.
EA 2415, Aide à la Décision pour une Médecine Personnalisée, Université de Montpellier, 34093 Montpellier, France.
Int J Environ Res Public Health. 2021 Oct 24;18(21):11157. doi: 10.3390/ijerph182111157.
This review aims to clarify the nature of the link between Alzheimer's disease and the oral microbiome on an epidemiological and pathophysiological level, as well as to highlight new therapeutic perspectives that contribute to the management of this disease. We performed a systematic review, following the Preferred Reporting Items for Systematic Reviews checklist, from January 2000 to July 2021. The terms "plaque," "saliva," and "mouth" were associated with the search term "oral diseases" and used in combination with the Boolean operator "AND"/"OR". We included experimental or clinical studies and excluded conferences, abstracts, reviews, and editorials. A total of 27 articles were selected. Evidence for the impact of the oral microbiome on the pathophysiological and immunoinflammatory mechanisms of Alzheimer's disease is accumulating. The impact of the oral microbiome on the development of AD opens the door to complementary therapies such as phototherapy and/or the use of prebiotic compounds and probiotic strains for global or targeted modulation of the oral microbiome in order to have a favourable influence on the evolution of this pathology in the future.
本综述旨在从流行病学和病理生理学层面阐明阿尔茨海默病与口腔微生物组之间的关联性质，并强调有助于这种疾病管理的新治疗前景。我们遵循系统评价的首选报告项目清单，从 2000 年 1 月到 2021 年 7 月进行了系统评价。术语“斑块”、“唾液”和“口腔”与搜索词“口腔疾病”相关联，并与布尔运算符“AND”/“OR”结合使用。我们纳入了实验或临床研究，排除了会议、摘要、综述和社论。共选择了 27 篇文章。口腔微生物组对阿尔茨海默病病理生理和免疫炎症机制的影响的证据正在积累。口腔微生物组对 AD 发展的影响为光疗和/或使用益生元和益生菌菌株等补充疗法开辟了道路，以便对口腔微生物组进行全局或靶向调节，从而对未来这种病理学的发展产生有利影响。
