Feder H M
Department of Pediatrics, University of Connecticut Health Center, Farmington 06032.
Rev Infect Dis. 1987 Jul-Aug;9(4):783-6. doi: 10.1093/clinids/9.4.783.
Bacteroides fragilis is a rare cause of bacterial meningitis. In the antibiotic era nine cases have been reported. Seven of these nine cases occurred in premature infants and neonates. Of the nine patients with B. fragilis meningitis, two died, four survived with neurologic sequelae, and three survived without sequelae. Predisposing conditions included abdominal sepsis, chronic otitis media, and ventriculoatrial shunt infection. Metronidazole, which is bactericidal, has been the most effective therapy for B. fragilis meningitis.
脆弱拟杆菌是细菌性脑膜炎的罕见病因。在抗生素时代，已有9例病例报告。这9例病例中有7例发生在早产儿和新生儿中。在9例脆弱拟杆菌脑膜炎患者中，2例死亡，4例存活但有神经后遗症，3例存活且无后遗症。易感因素包括腹部脓毒症、慢性中耳炎和脑室心房分流感染。具有杀菌作用的甲硝唑一直是治疗脆弱拟杆菌脑膜炎最有效的疗法。
