Wang Qian, Sartorius Benn, Day Nicholas Philip John, Maude Richard James
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Wellcome Open Res. 2024 Sep 12;7:285. doi: 10.12688/wellcomeopenres.18533.2. eCollection 2022.
Scrub typhus is a neglected life-threatening vector-borne disease mainly caused by the bacterium , which is occasionally transmitted to humans during feeding of larval mites. It has been estimated that more than 1 billion persons are potentially threatened and 1 million clinical cases occur annually across the world; however, it is unclear how this estimate was computed (and what the original source was) and much remains unknown regarding its global burden and risk factors. This systematic review aims to provide a comprehensive overview of the spatial-temporal distribution of scrub typhus, associated burden and risk factors at global, national and subnational resolutions, and to review the burden estimation models used at those different scales.
A systematic search for literature on scrub typhus occurrence, risk factors and modelling methods will be conducted. PubMed and five other databases will be searched for published literature, and Google Scholar and nine other databases will be used to search for grey literatures. All titles/abstracts of the searched records will be separately assessed by two reviewers, who will then screen the full-text of potential records to decide eligibility. A pre-formatted spreadsheet will be used by one reviewer to extract data from qualifying research, with a second reviewer checking the results. Data will be tabulated, synthesized descriptively, and summarized narratively for each review question. Where appropriate, meta-analyses will be conducted. The risk of bias will be assessed, and potential publication bias will be detected.
This review will provide a comprehensive understanding of the current occurrence, spatial-temporal distribution, and burden of scrub typhus, identify associated risk factors from global to subnational resolutions, consolidate the best practice modeling framework(s) to estimate the burden of scrub typhus at various geographic/temporal resolutions, and decompose the relative contributions of various risk factors at scale.
CRD42022315209.
恙虫病是一种被忽视的、危及生命的媒介传播疾病，主要由 细菌引起，幼虫恙螨在叮咬人类时偶尔会传播该病菌。据估计，全球超过10亿人面临潜在威胁，每年有100万临床病例；然而，尚不清楚该估计是如何计算得出的（以及原始数据来源是什么），关于其全球负担和风险因素仍有许多未知之处。本系统评价旨在全面概述恙虫病在全球、国家和次国家层面的时空分布、相关负担及风险因素，并回顾在这些不同尺度上使用的负担估计模型。
将对有关恙虫病发生情况、风险因素和建模方法的文献进行系统检索。将在PubMed和其他五个数据库中检索已发表的文献，并使用谷歌学术搜索和其他九个数据库来搜索灰色文献。两位评审员将分别对检索记录的所有标题/摘要进行评估，然后筛选潜在记录的全文以确定是否符合要求。一位评审员将使用预先格式化的电子表格从符合条件的研究中提取数据，另一位评审员将检查结果。将对数据进行列表、描述性综合和叙述性总结，以回答每个审查问题。在适当情况下，将进行荟萃分析。将评估偏倚风险，并检测潜在的发表偏倚。
本综述将全面了解恙虫病的当前发病情况、时空分布和负担，从全球到次国家层面确定相关风险因素，整合最佳实践建模框架以估计不同地理/时间分辨率下的恙虫病负担，并在不同尺度上分解各种风险因素的相对贡献。
PROSPERO注册编号：CRD42022315209。
