Department of Rehabilitation, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada.
Center for Interdisciplinary Research in Rehabilitation and Social Integration, Quebec Rehabilitation Institute, Quebec City, Quebec, Canada.
J Foot Ankle Res. 2020 Dec 1;13(1):69. doi: 10.1186/s13047-020-00436-6.
Single-blind parallel group randomized clinical trial.
To compare the effects of neurocryostimulation (NCS) with those of traditional ice application on functional recovery, pain, edema and ankle dorsiflexion range of motion (ROM) in individuals receiving physiotherapy treatments for acute lateral ankle sprains (LAS).
Ankle sprain is a very common injury and its management is often costly, with important short- and long-term impacts on individuals and society. As new methods of therapy using cold (cryotherapy) are emerging for the treatment of musculoskeletal conditions, little evidence exists to support their use. NCS, which provokes a rapid cooling of the skin with the liberation of pressured CO, is a method believed to accelerate the resorption of edema and recovery in the case of traumatic injuries.
Forty-one participants with acute LAS were randomly assigned either to a group that received in-clinic physiotherapy treatments and NCS (experimental NCS group, n = 20), or to a group that received the same in-clinic physiotherapy treatments and traditional ice application (comparison ice group, n = 21). Primary (Lower Extremity Functional Scale - LEFS) and secondary (visual analog scale for pain intensity at rest and during usual activities in the last 48 h, Figure of Eight measurement of edema, and weight bearing lunge for ankle dorsiflexion range of motion) outcomes were evaluated at baseline (T0), after one week (T1), two weeks (T2), four weeks (T4) and finally, after six weeks (T6). The effects of interventions were assessed using two-way ANOVA-type Nonparametric Analysis for Longitudinal Data (nparLD).
No significant group-time interaction or group effect was observed for all outcomes (0.995 ≥ p ≥ 0.057) following the intervention. Large time effects were however observed for all outcomes (p < 0.0001).
Results suggest that neurocryostimulation is no more effective than traditional ice application in improving functional recovery, pain, edema, and ankle dorsiflexion ROM during the first six weeks of physiotherapy treatments in individuals with acute LAS.
Therapy, level 1b.
ClinicalTrials.gov , NCT02945618 . Registered 23 October 2016 - Retrospectively registered (25 participants recruited prior to registration, 17 participants after).
单盲平行组随机临床试验。
比较神经冷冻疗法（NCS）与传统冰敷对接受物理治疗的急性外踝扭伤（LAS）患者的功能恢复、疼痛、肿胀和踝关节背屈活动范围（ROM）的影响。
踝关节扭伤是一种非常常见的损伤，其治疗费用通常很高，对个人和社会都有重要的短期和长期影响。随着使用冷（冷冻疗法）治疗肌肉骨骼疾病的新疗法的出现，很少有证据支持其使用。NCS 通过释放加压 CO 来快速冷却皮肤，是一种被认为可以加速创伤性损伤中水肿吸收和恢复的方法。
41 名急性 LAS 患者被随机分配到接受门诊物理治疗和 NCS 的组（实验组 NCS 组，n=20）或接受相同门诊物理治疗和传统冰敷的组（对照组冰敷组，n=21）。主要（下肢功能量表 - LEFS）和次要（疼痛强度视觉模拟评分，休息时和过去 48 小时内日常活动时，八字测量肿胀，负重弓步测量踝关节背屈活动范围）结局在基线（T0）、1 周后（T1）、2 周后（T2）、4 周后（T4）和最后 6 周后（T6）进行评估。使用纵向数据非参数分析（nparLD）的双向方差分析型评估干预措施的效果。
干预后，所有结局均未观察到组间时间交互作用或组间效应（0.995≥p≥0.057）。然而，所有结局均观察到较大的时间效应（p<0.0001）。
结果表明，在急性 LAS 患者接受物理治疗的前 6 周内，神经冷冻疗法在改善功能恢复、疼痛、肿胀和踝关节背屈 ROM 方面并不优于传统冰敷。
治疗，1b 级。
ClinicalTrials.gov，NCT02945618。2016 年 10 月 23 日注册 - 回顾性注册（注册前招募了 25 名参与者，注册后招募了 17 名参与者）。
