Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
Department of Biomedicine, University of Basel and Division of Oncology, University Hospital Basel, Basel, Switzerland.
Cancer Discov. 2020 Dec;10(12):1789-1790. doi: 10.1158/2159-8290.CD-20-1355.
Song and colleagues describe how N-glycans stabilize expression of checkpoint molecule B7-H4 that suppresses T-cell function. Inhibiting N-glycan stabilization of B7-H4 generates an immune hot cancer that is more responsive to combination therapies..
宋等人描述了 N-糖基化如何稳定抑制 T 细胞功能的检查点分子 B7-H4 的表达。抑制 B7-H4 的 N-糖基化稳定会产生更易对联合疗法产生反应的免疫热肿瘤。
