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Use of dexamethasone, remdesivir, convalescent plasma and prone positioning in the treatment of severe COVID-19 infection in pregnancy: A case report.地塞米松、瑞德西韦、康复期血浆及俯卧位通气在妊娠合并重症新型冠状病毒肺炎感染治疗中的应用:一例病例报告
Case Rep Womens Health. 2021 Jan;29:e00273. doi: 10.1016/j.crwh.2020.e00273. Epub 2020 Nov 25.
2
Placental pathology in a pregnant woman with severe COVID-19 and successful ECMO treatment: a case report.一名重症 COVID-19 孕妇的胎盘病理学和 ECMO 治疗成功:病例报告。
BMC Pregnancy Childbirth. 2021 Nov 10;21(1):760. doi: 10.1186/s12884-021-04228-z.
3
Critical respiratory failure in pregnancy complicated with COVID-19: A case report.妊娠合并新型冠状病毒肺炎致重症呼吸衰竭:1例病例报告
Case Rep Womens Health. 2021 Apr;30:e00309. doi: 10.1016/j.crwh.2021.e00309. Epub 2021 Mar 23.
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High dose dexamethasone treatment for Acute Respiratory Distress Syndrome secondary to COVID-19: a structured summary of a study protocol for a randomised controlled trial.COVID-19 继发急性呼吸窘迫综合征的高剂量地塞米松治疗:一项随机对照试验研究方案的结构化总结。
Trials. 2020 Aug 26;21(1):743. doi: 10.1186/s13063-020-04646-y.
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Severe Acute Respiratory Distress Syndrome Secondary to Coronavirus 2 (SARS-CoV-2).新型冠状病毒2型(SARS-CoV-2)继发的严重急性呼吸窘迫综合征
Int J Occup Environ Med. 2020 Oct;11(4):157-178. doi: 10.34172/ijoem.2020.2202.
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Management of Critically Ill Pregnant Patients with COVID-19 Infection in a Rural State.农村州 COVID-19 感染危重症孕妇的管理。
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Recurrent pneumothorax after cesarean delivery in the critically ill pregnant with severe COVID-19 ARDS: a case report.重症新型冠状病毒肺炎急性呼吸窘迫综合征的危重孕妇剖宫产术后复发性气胸:一例报告
Eur Rev Med Pharmacol Sci. 2022 Mar;26(5):1765-1769. doi: 10.26355/eurrev_202203_28247.
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Early severe acute respiratory distress syndrome: What's going on? Part I: pathophysiology.早期重症急性呼吸窘迫综合征:究竟是怎么回事?第一部分:病理生理学
Anaesthesiol Intensive Ther. 2016;48(5):314-338. doi: 10.5603/AIT.2016.0056.
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Treatment Experience With Inhaled Corticosteroids in Combination with Remdesivir and Dexamethasone Among COVID-19 Patients Admitted to a Rural Community Hospital: A Case Series.一家农村社区医院收治的新冠肺炎患者使用吸入性糖皮质激素联合瑞德西韦和地塞米松的治疗经验:病例系列
Cureus. 2020 Nov 30;12(11):e11787. doi: 10.7759/cureus.11787.
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Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial.地塞米松对中重度 COVID-19 相关急性呼吸窘迫综合征患者存活天数和无呼吸机天数的影响:CoDEX 随机临床试验。
JAMA. 2020 Oct 6;324(13):1307-1316. doi: 10.1001/jama.2020.17021.

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A review of COVID-19 therapeutics in pregnancy and lactation.妊娠期和哺乳期COVID-19治疗方法综述。
Obstet Med. 2022 Dec;15(4):225-232. doi: 10.1177/1753495X211056211. Epub 2022 Jan 12.
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Pregnancy and COVID-19.妊娠与新型冠状病毒肺炎
J Clin Med. 2022 Nov 9;11(22):6645. doi: 10.3390/jcm11226645.
3
The use of remdesivir among pregnant women and associated clinical outcomes in mother and the child.瑞德西韦在孕妇中的使用及其对母婴相关临床结局的影响。
Ann Med Surg (Lond). 2022 May;77:103681. doi: 10.1016/j.amsu.2022.103681. Epub 2022 Apr 28.
4
Pregnancy and COVID-19, focus on vaccine and pharmacological treatment.妊娠与 COVID-19,关注疫苗和药物治疗。
J Reprod Immunol. 2022 Jun;151:103630. doi: 10.1016/j.jri.2022.103630. Epub 2022 Apr 21.
5
Remdesivir for pregnancy: A systematic review of antiviral therapy for COVID-19.妊娠期使用瑞德西韦:对 COVID-19 抗病毒治疗的系统评价。
Heliyon. 2022 Jan;8(1):e08835. doi: 10.1016/j.heliyon.2022.e08835. Epub 2022 Jan 26.
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PEGylated green halloysite/spinel ferrite nanocomposites for pH sensitive delivery of dexamethasone: A potential pulmonary drug delivery treatment option for COVID-19.聚乙二醇化绿色埃洛石/尖晶石铁氧体纳米复合材料用于地塞米松的pH敏感递送:一种用于COVID-19的潜在肺部药物递送治疗选择。
Appl Clay Sci. 2022 Jan;216:106333. doi: 10.1016/j.clay.2021.106333. Epub 2021 Nov 9.
7
Understanding an evolving pandemic: An analysis of the clinical time delay distributions of COVID-19 in the United Kingdom.了解不断演变的大流行:对英国 COVID-19 临床时间延迟分布的分析。
PLoS One. 2021 Oct 20;16(10):e0257978. doi: 10.1371/journal.pone.0257978. eCollection 2021.
8
High-Dose Corticosteroids for a Pregnant Woman Critically Ill With Coronavirus Disease 2019.大剂量皮质类固醇用于一名患2019冠状病毒病的重症孕妇
Cureus. 2021 Aug 23;13(8):e17398. doi: 10.7759/cureus.17398. eCollection 2021 Aug.
9
Critical COVID-19 in a 24-week pregnant woman with 32 days of invasive mechanical ventilation before delivery of fetus: a case of successful collaborative multidisciplinary care.一位怀孕 24 周的孕妇患有重症 COVID-19,在分娩前接受了 32 天的有创机械通气:成功协作多学科护理的案例。
BMJ Case Rep. 2021 Sep 8;14(9):e243516. doi: 10.1136/bcr-2021-243516.
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A review of remdesivir for COVID-19 in pregnancy and lactation.关于瑞德西韦在妊娠期和哺乳期 COVID-19 中的应用的综述。
J Antimicrob Chemother. 2021 Dec 24;77(1):24-30. doi: 10.1093/jac/dkab311.

本文引用的文献

1
COVID-19: An overview of the current pharmacological interventions, vaccines, and clinical trials.新型冠状病毒肺炎:当前药理学干预措施、疫苗和临床试验概述。
Biochem Pharmacol. 2020 Oct;180:114184. doi: 10.1016/j.bcp.2020.114184. Epub 2020 Jul 30.
2
Compassionate Use of Remdesivir for Patients with Severe Covid-19.瑞德西韦在治疗重症 COVID-19 患者中的同情使用。
N Engl J Med. 2020 Jun 11;382(24):2327-2336. doi: 10.1056/NEJMoa2007016. Epub 2020 Apr 10.
3
Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations.2019 冠状病毒病(COVID-19)的重症监护管理:挑战与建议。
Lancet Respir Med. 2020 May;8(5):506-517. doi: 10.1016/S2213-2600(20)30161-2. Epub 2020 Apr 6.
4
Convalescent plasma as a potential therapy for COVID-19.康复期血浆作为治疗新冠肺炎的一种潜在疗法。
Lancet Infect Dis. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. Epub 2020 Feb 27.
5
Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial.地塞米松治疗急性呼吸窘迫综合征:一项多中心、随机对照试验。
Lancet Respir Med. 2020 Mar;8(3):267-276. doi: 10.1016/S2213-2600(19)30417-5. Epub 2020 Feb 7.
6
Committee Opinion No. 713: Antenatal Corticosteroid Therapy for Fetal Maturation.委员会意见第713号:用于胎儿成熟的产前糖皮质激素治疗
Obstet Gynecol. 2017 Aug;130(2):e102-e109. doi: 10.1097/AOG.0000000000002237.
7
Treatment of ARDS With Prone Positioning.俯卧位通气治疗急性呼吸窘迫综合征
Chest. 2017 Jan;151(1):215-224. doi: 10.1016/j.chest.2016.06.032. Epub 2016 Jul 8.
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Prolonged glucocorticoid treatment is associated with improved ARDS outcomes: analysis of individual patients' data from four randomized trials and trial-level meta-analysis of the updated literature.长期糖皮质激素治疗与改善 ARDS 结局相关:四项随机试验的个体患者数据分析和更新文献的试验水平荟萃分析。
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Does prone positioning improve oxygenation and reduce mortality in patients with acute respiratory distress syndrome?俯卧位通气能否改善急性呼吸窘迫综合征患者的氧合并降低死亡率?
Can Respir J. 2014 Jul-Aug;21(4):213-5. doi: 10.1155/2014/472136. Epub 2014 Jun 13.
10
Long-term outcomes after repeat doses of antenatal corticosteroids.重复剂量产前皮质类固醇激素后的长期结局。
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地塞米松、瑞德西韦、康复期血浆及俯卧位通气在妊娠合并重症新型冠状病毒肺炎感染治疗中的应用:一例病例报告

Use of dexamethasone, remdesivir, convalescent plasma and prone positioning in the treatment of severe COVID-19 infection in pregnancy: A case report.

作者信息

Jacobson Jennifer, Antony Kathleen, Beninati Michael, Alward William, Hoppe Kara K

机构信息

Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America.

Department of Pulmonology and Critical Care, School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States of America.

出版信息

Case Rep Womens Health. 2021 Jan;29:e00273. doi: 10.1016/j.crwh.2020.e00273. Epub 2020 Nov 25.

DOI:10.1016/j.crwh.2020.e00273
PMID:33262932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7687655/
Abstract

Severe infection with COVID-19 virus in pregnancy offers unique management challenges for the obstetrician and critical care specialist. We report the case of a woman at 26 weeks of gestation with acute respiratory distress syndrome secondary to COVID-19 infection treated with dexamethasone, remdesivir, convalescent plasma and mechanical ventilation. Cesarean delivery was performed at 29 weeks due to worsening maternal status. This case offers insight into the assessment and successful use of treatment strategies, including dexamethasone, remdesivir, convalescent plasma, early prone positioning, conservative fluid management, permissive hypoxia and low tidal volume parameters with ventilator support for pregnancies affected by severe COVID-19 infection.

摘要

妊娠期感染新型冠状病毒肺炎病毒会给产科医生和重症监护专家带来独特的管理挑战。我们报告了一例妊娠26周的女性病例,该患者因新型冠状病毒肺炎感染继发急性呼吸窘迫综合征,接受了地塞米松、瑞德西韦、康复期血浆治疗及机械通气。由于产妇病情恶化,于孕29周行剖宫产。该病例为评估和成功使用治疗策略提供了见解,这些策略包括地塞米松、瑞德西韦、康复期血浆、早期俯卧位、保守液体管理、允许性低氧血症以及在呼吸机支持下采用低潮气量参数,用于治疗受严重新型冠状病毒肺炎感染影响的妊娠患者。