Tianjin Key Laboratory of Urban Transport Emission Research, State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin, China.
Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China.
J Appl Toxicol. 2021 May;41(5):668-682. doi: 10.1002/jat.4110. Epub 2020 Dec 1.
Fine particulate matter ≤2.5 μm (PM ) air pollution is regarded as one of the prominent risk factors that contributes to morbidity and mortality globally, among which cardiovascular disease (CVD) has been strongly associated with PM exposure and is a leading cause of death. Atherosclerosis (AS), the common pathological basis of many CVDs, is a progressive syndrome characterized by the accumulation of lipids and fibrous plaque in the arteries. Recent epidemiological and toxicological studies suggest that PM may also contribute to the development of AS, even at levels below the current air quality standards. In this paper, the complete pathological process of atherosclerotic plaque from occurrence to rupture leading to CVD was elaborated. Then, the growing epidemiological evidence linking PM to AS in humans was reviewed and summarized. Furthermore, the potential mechanisms of PM -mediated AS were discussed, including oxidative stress, inflammation, endothelial dysfunction, abnormal lipid metabolism, disturbance of the autonomic nervous system, and abnormal coagulation function. This paper aimed to provide a comprehensive view of the effect of PM on the occurrence and development of AS for better prevention and mitigation of adverse health impacts due to PM air pollution.
细颗粒物≤2.5μm（PM）空气污染被认为是导致全球发病率和死亡率的显著危险因素之一，其中心血管疾病（CVD）与 PM 暴露密切相关，是主要的死亡原因之一。动脉粥样硬化（AS）是许多 CVD 的常见病理基础，是一种以动脉中脂质和纤维斑块积累为特征的进行性综合征。最近的流行病学和毒理学研究表明，即使在低于当前空气质量标准的水平下，PM 也可能导致 AS 的发展。本文详细阐述了动脉粥样硬化斑块从发生到破裂导致 CVD 的完整病理过程。然后，综述了越来越多的将 PM 与人类 AS 联系起来的流行病学证据。此外，还讨论了 PM 介导的 AS 的潜在机制，包括氧化应激、炎症、内皮功能障碍、脂质代谢异常、自主神经系统紊乱和凝血功能异常。本文旨在为 PM 对动脉粥样硬化发生和发展的影响提供全面的认识，以更好地预防和减轻 PM 空气污染对健康的不利影响。
