Naserinejad Nazgol, Costanian Christy, Birot Olivier, Barboni Toussaint, Roudier Emilie
School of Global Health, Faculty of Health, York University, Toronto, ON, Canada.
Department of Family and Community Medicine, St. Michael's Hospital, Toronto, ON, Canada.
Front Physiol. 2023 Jul 19;14:1225195. doi: 10.3389/fphys.2023.1225195. eCollection 2023.
Climate change favors weather conditions conducive to wildland fires. The intensity and frequency of forest fires are increasing, and fire seasons are lengthening. Exposure of human populations to smoke emitted by these fires increases, thereby contributing to airborne pollution through the emission of gas and particulate matter (PM). The adverse health outcomes associated with wildland fire exposure represent an important burden on the economies and health systems of societies. Even though cardiovascular diseases (CVDs) are the main of cause of the global burden of diseases attributable to PM exposure, it remains difficult to show reliable associations between exposure to wildland fire smoke and cardiovascular disease risk in population-based studies. Optimal health requires a resilient and adaptable network of small blood vessels, namely, the microvasculature. Often alterations of this microvasculature precede the occurrence of adverse health outcomes, including CVD. Biomarkers of microvascular health could then represent possible markers for the early detection of poor cardiovascular outcomes. This review aims to synthesize the current literature to gauge whether assessing the microvasculature can better estimate the cardiovascular impact of wildland fires.
气候变化有利于形成有利于野火发生的天气条件。森林火灾的强度和频率在增加，火灾季节在延长。人类暴露于这些火灾所排放烟雾中的情况增多，从而通过气体和颗粒物（PM）排放导致空气污染。与暴露于野火相关的不良健康后果给社会的经济和卫生系统带来了重大负担。尽管心血管疾病（CVD）是因暴露于PM而导致的全球疾病负担的主要原因，但在基于人群的研究中，仍难以证明暴露于野火烟雾与心血管疾病风险之间存在可靠关联。最佳健康状态需要一个有弹性且适应性强的小血管网络，即微血管系统。这种微血管系统的改变通常在包括心血管疾病在内的不良健康后果出现之前就已发生。微血管健康的生物标志物可能是早期发现不良心血管结局的潜在标志物。本综述旨在综合当前文献，以评估评估微血管系统是否能更好地估计野火对心血管的影响。
