Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.
Department of Otolaryngology-Head and Neck Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.
Pediatr Pulmonol. 2021 Feb;56 Suppl 1:S23-S31. doi: 10.1002/ppul.25028.
Sleep-disordered breathing (SBD) is an under recognized comorbidity in the cystic fibrosis (CF) population across the lifespan. Nocturnal hypoxemia, obstructive sleep apnea, and nocturnal hypoventilation are respiratory abnormalities that occur commonly during sleep in patients with lung disease, and have deleterious consequences to the quality of life in people with CF. Effective screening for these abnormalities is needed to allow for timely initiation of treatment, which has been reported to be efficacious. Lack of treatment leads to worsened pulmonary, cardiovascular, and metabolic outcomes in patients. In this review, we give an overview of SBD for the CF clinician, including prevalence, treatment, and suggestions for future research. We strongly encourage the CF community to incorporate evaluation for SBD in CF clinical care so that outcomes for the subset of the CF patients with comorbid SBD improve.
睡眠障碍性呼吸（SBD）是整个生命周期中囊性纤维化（CF）人群中未被充分认识的合并症。夜间低氧血症、阻塞性睡眠呼吸暂停和夜间通气不足是肺部疾病患者睡眠中常见的呼吸异常，对 CF 患者的生活质量有不良影响。需要有效的筛查这些异常，以便及时开始治疗，据报道治疗是有效的。缺乏治疗会导致患者的肺部、心血管和代谢结果恶化。在这篇综述中，我们为 CF 临床医生概述了 SBD，包括患病率、治疗和未来研究的建议。我们强烈鼓励 CF 社区将 SBD 的评估纳入 CF 临床护理中，以便改善合并 SBD 的 CF 患者亚组的结果。
