Pediatric Pulmonology, Sleep and Cystic Fibrosis Center, Department of Pediatrics, Hadassah Medical Center, Jerusalem, Israel.
Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Pediatr Pulmonol. 2022 Aug;57(8):1944-1951. doi: 10.1002/ppul.25462. Epub 2021 May 20.
Cystic fibrosis (CF) is a chronic multisystem disease with manifestations from birth. It involves the entire respiratory system, with increased cough, and recurrent pulmonary infections, and it also leads to intestinal malabsorption, all of which can have an impact on sleep. In this review, we summarize the available literature on the various sleep disturbances in children with CF. Sleep quality and sleep efficiency are often impaired in children with CF. They may be accompanied by symptoms associated with sleep-disordered breathing (SDB), and objective findings, such as nocturnal hypoxemia. Importantly, a strong association has been shown between SDB and the severity of lung disease, and some studies have reported a similar association for sleep quality. Further research is needed to better characterize the association of sleep disturbances with respiratory outcomes and the impact of treatment of sleep disorders on pulmonary status in children with CF.
囊性纤维化（CF）是一种从出生起就表现出的慢性多系统疾病。它涉及整个呼吸系统，导致频繁咳嗽和反复肺部感染，还会导致肠道吸收不良，所有这些都会影响睡眠。在这篇综述中，我们总结了 CF 患儿各种睡眠障碍的现有文献。CF 患儿的睡眠质量和睡眠效率往往受到影响。他们可能伴有与睡眠呼吸障碍（SDB）相关的症状，以及客观发现，如夜间低氧血症。重要的是，已经表明 SDB 与肺部疾病的严重程度之间存在很强的关联，一些研究还报告了睡眠质量的类似关联。需要进一步的研究来更好地描述睡眠障碍与呼吸结果的关联，以及治疗睡眠障碍对 CF 患儿肺部状况的影响。
