Davidesko Sharon, Nahum Sacks Kira, Friger Michael, Haim Alon, Sheiner Eyal
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva, Israel.
Department of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev , Beer Sheva, Israel.
Hypertens Pregnancy. 2021 Feb;40(1):21-28. doi: 10.1080/10641955.2020.1854300. Epub 2020 Dec 2.
: To analyze preeclampsia as a risk factor for pediatric endocrine disease. : A population-based cohort analysis comparing the risk of endocrine morbidity of children born between 1991-2014 to mothers with and without preeclampsia. : The study included 253,808 deliveries. Exposed offspring had significantly more endocrine hospitalizations (0.7% vs 0.4%; < 0.001), specifically obesity (0.4% vs 0.2%, < 0.001). While controlling for confounders, the exposed offspring had significantly more endocrine morbidity (OR 1.433 95% CI 1.115-1.841 = 0.005). : Preeclampsia is an independent risk factor for long-term endocrine disease of the offspring, specifically obesity.
分析子痫前期作为小儿内分泌疾病的一个风险因素。：一项基于人群的队列分析，比较1991年至2014年间出生的母亲患有和未患有子痫前期的儿童发生内分泌疾病的风险。：该研究包括253,808例分娩。暴露组后代的内分泌住院率显著更高（0.7%对0.4%；<0.001），尤其是肥胖（0.4%对0.2%，<0.001）。在控制混杂因素后，暴露组后代的内分泌疾病发生率显著更高（OR 1.433，95%CI 1.115 - 1.841，=0.005）。：子痫前期是后代长期内分泌疾病的独立风险因素，尤其是肥胖。
