National Institute of Science and Technology in Nano-Biopharmaceutics (INCT-NanoBiofar) - Laboratory of Hypertension, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Hospital Mater Dei, Intensive Care Unit, Belo Horizonte, Brazil.
Clin Sci (Lond). 2020 Dec 11;134(23):3063-3078. doi: 10.1042/CS20200478.
In 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin-angiotensin system (RAS) today. ACE2 is an important molecular hub that connects the RAS classical arm, formed mainly by the octapeptide angiotensin II (Ang II) and its receptor AT1, with the RAS alternative or protective arm, formed mainly by the heptapeptides Ang-(1-7) and alamandine, and their receptors, Mas and MrgD, respectively. In this work we reviewed classical and modern literature to describe how ACE2 is a critical component of the protective arm, particularly in the context of the cardiac function, coagulation homeostasis and immune system. We also review recent literature to present a critical view of the role of ACE2 and RAS in the SARS-CoV-2 pandemic.
2020 年，我们迎来了血管紧张素转换酶 2（ACE2）发现 20 周年。这一事件是一个里程碑，改变了我们今天对肾素-血管紧张素系统（RAS）的看法。ACE2 是一个重要的分子枢纽，连接着 RAS 的经典臂，主要由八肽血管紧张素 II（Ang II）及其受体 AT1 组成，以及 RAS 的替代或保护臂，主要由七肽血管紧张素-(1-7)和alamandine 及其受体 Mas 和 MrgD 组成。在这项工作中，我们回顾了经典和现代文献，描述了 ACE2 如何成为保护臂的关键组成部分，特别是在心脏功能、凝血稳态和免疫系统方面。我们还回顾了最近的文献，对 ACE2 和 RAS 在 SARS-CoV-2 大流行中的作用提出了批判性的看法。
