Yao Xinyu, Cao Xinyi, Chen Liang, Liao Wang
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
Public Service Platform of South China Sea for R&D Marine Biomedicine Resources, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.
Nutrients. 2024 Dec 29;17(1):97. doi: 10.3390/nu17010097.
Food protein-derived antihypertensive peptides have attracted substantial attention as a safer alternative for drugs. The regulation of the renin-angiotensin system (RAS) is an essential aspect underlying the mechanisms of antihypertensive peptides. Most of the identified antihypertensive peptides exhibit the angiotensin-converting enzyme (ACE) inhibitory effect. In addition, artificial intelligence has improved the efficiency of ACE inhibitory peptide identifications. Moreover, the inhibition of renin and blockade or down-regulation of angiotensin type I receptor (AT1R) have also been demonstrated to be effective intervention strategies. With the identification of the ACE2/Ang (1-7)/MasR axis, activation or up-regulation of angiotensin-converting enzyme 2 (ACE2) has also emerged as a new intervention pathway. This review summarizes the research progress of antihypertensive peptides in intervening with hypertension from the perspective of their properties, sources, and key factors. The objective of this review is to provide theoretical references for the development of antihypertensive peptides and the explorations of the molecular mechanisms.
食物蛋白衍生的降压肽作为一种更安全的药物替代品已引起广泛关注。肾素-血管紧张素系统（RAS）的调节是降压肽作用机制的一个重要方面。大多数已鉴定的降压肽具有血管紧张素转换酶（ACE）抑制作用。此外，人工智能提高了ACE抑制肽鉴定的效率。而且，抑制肾素以及阻断或下调血管紧张素I型受体（AT1R）也已被证明是有效的干预策略。随着ACE2/Ang（1-7）/MasR轴的发现，激活或上调血管紧张素转换酶2（ACE2）也成为一种新的干预途径。本综述从降压肽的性质、来源和关键因素等方面总结了其干预高血压的研究进展。本综述的目的是为降压肽的开发和分子机制的探索提供理论参考。
