Department of Hypertension, The First Affiliated Hospital of Dalian Medical University, DaLian Liaoning 116011, China.
Department of Hypertension, The First Affiliated Hospital of Dalian Medical University, DaLian Liaoning 116011, China.
Pregnancy Hypertens. 2021 Mar;23:73-78. doi: 10.1016/j.preghy.2020.11.007. Epub 2020 Nov 25.
Atrial natriuretic peptide (ANP) regulates water-salt balance and blood pressure by promoting renal sodium and water excretion.
Our study was to investigate plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) and corin in hypertensive disorders of pregnancy (HDP) patients. Furthermore, the relationship between corin/NT-proANP and neonatal adverse prognosis were evaluated.
Seventy-seven HDP patients and forty-eight normotensive women as control group were recruited. Clinical characteristic and plasma were collected. Plasma NT-proANP and corin were determined by ELISA. Gestational age, neonatal weight and APGAR scores were recorded. Statistical analysis was conducted.
NT-proANP and corin were significantly increased in HDP group compared with that of control (P < 0.05). NT-proANP and corin were significantly elevated in HDP patients who suffered from premature delivery (P < 0.05). Both NT-proANP and corin were negatively associated with delivery time, neonatal weight and APGAR scores in HDP group. Multiple regressions demonstrated that NT-proANP and corin were independent risk factor of delivery time, neonatal weight and APGAR scores.
Plasma NT-proANP and corin were significantly increased in HDP. NT-proANP and corin were associated with neonatal adverse events in HDP patients. Thus, NT-proANP and corin may become new biomarkers for evaluating severity of pregnancy and neonatal adverse events in HDP patients.
心钠肽（ANP）通过促进肾脏钠和水的排泄来调节水盐平衡和血压。
本研究旨在探讨妊娠高血压疾病（HDP）患者血浆 N 端脑钠肽前体（NT-proANP）和心钠肽酶（corin）的变化，并评估其与新生儿不良预后的关系。
收集 77 例 HDP 患者和 48 例正常妊娠妇女作为对照组，记录临床特征和血浆，采用 ELISA 法检测血浆 NT-proANP 和 corin，记录新生儿胎龄、体重和 Apgar 评分。进行统计学分析。
与对照组相比，HDP 组 NT-proANP 和 corin 明显升高（P<0.05）。HDP 患者中早产组 NT-proANP 和 corin 明显升高（P<0.05）。NT-proANP 和 corin 与 HDP 组的分娩时间、新生儿体重和 Apgar 评分呈负相关。多元回归分析表明，NT-proANP 和 corin 是分娩时间、新生儿体重和 Apgar 评分的独立危险因素。
HDP 患者血浆 NT-proANP 和 corin 明显升高，与新生儿不良事件相关。因此，NT-proANP 和 corin 可能成为评估 HDP 患者妊娠严重程度和新生儿不良事件的新生物标志物。
