Zhang Xianrui, Gu Xiabing, Zhang Yikai, Dong Ningzheng, Wu Qingyu
Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou 215123, China.
MOH Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Biology (Basel). 2022 May 7;11(5):717. doi: 10.3390/biology11050717.
Atrial natriuretic peptide (ANP) is a crucial element of the cardiac endocrine function that promotes natriuresis, diuresis, and vasodilation, thereby protecting normal blood pressure and cardiac function. Corin is a type II transmembrane serine protease that is highly expressed in the heart, where it converts the ANP precursor to mature ANP. Corin deficiency prevents ANP activation and causes hypertension and heart disease. In addition to the heart, corin is expressed in other tissues, including those of the kidney, skin, and uterus, where corin-mediated ANP production and signaling act locally to promote sodium excretion and vascular remodeling. These results indicate that corin and ANP function in many tissues via endocrine and autocrine mechanisms. In heart failure patients, impaired natriuretic peptide processing is a common pathological mechanism that contributes to sodium and body fluid retention. In this review, we discuss most recent findings regarding the role of corin in non-cardiac tissues, including the kidney and skin, in regulating sodium homeostasis and body fluid excretion. Moreover, we describe the molecular mechanisms underlying corin and ANP function in supporting orderly cellular events in uterine spiral artery remodeling. Finally, we assess the potential of corin-based approaches to enhance natriuretic peptide production and activity as a treatment of heart failure.
心房利钠肽（ANP）是心脏内分泌功能的关键要素，可促进利钠、利尿和血管舒张，从而维持正常血压和心脏功能。Corin是一种II型跨膜丝氨酸蛋白酶，在心脏中高度表达，可将ANP前体转化为成熟的ANP。Corin缺乏会阻止ANP激活，并导致高血压和心脏病。除心脏外，Corin还在其他组织中表达，包括肾脏、皮肤和子宫组织，在这些组织中，Corin介导的ANP产生和信号传导在局部发挥作用，以促进钠排泄和血管重塑。这些结果表明，Corin和ANP通过内分泌和自分泌机制在许多组织中发挥作用。在心力衰竭患者中，利钠肽加工受损是导致钠和体液潴留的常见病理机制。在这篇综述中，我们讨论了关于Corin在非心脏组织（包括肾脏和皮肤）中调节钠稳态和体液排泄作用的最新研究结果。此外，我们描述了Corin和ANP在支持子宫螺旋动脉重塑中有序细胞事件的分子机制。最后，我们评估了基于Corin的方法增强利钠肽产生和活性作为心力衰竭治疗手段的潜力。
