Niwa T, Nomura T, Ozawa Y, Maeda K, Shibata M, Yamada K, Oda O
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
Artif Organs. 1987 Dec;11(6):486-90. doi: 10.1111/j.1525-1594.1987.tb02714.x.
To improve the adsorption capacity of the artificial reticuloendothelial system containing phenylalanine as a ligand, a regeneration method for the adsorbent during plasma perfusion was developed. The adsorbed rheumatoid factor, immunoglobulins, and complements were demonstrated to be elutable from the adsorbent with a 5% glucose solution in vitro. The regeneration method was applied to the treatment of a patient with rheumatoid arthritis. During each plasma perfusion, the adsorbent was regenerated, usually twice, with a 5% glucose solution at a flow rate of 50 ml/min. After each regeneration, the adsorption capacity of the adsorbent was found to be improved by determining the pre- and post-column plasma titers of a rheumatoid arthritis hemagglutination test.
为提高含苯丙氨酸作为配体的人工网状内皮系统的吸附能力，开发了一种在血浆灌注过程中对吸附剂进行再生的方法。体外实验表明，吸附的类风湿因子、免疫球蛋白和补体可被5%葡萄糖溶液从吸附剂上洗脱下来。该再生方法应用于一名类风湿关节炎患者的治疗。在每次血浆灌注过程中，吸附剂用5%葡萄糖溶液以50 ml/min的流速进行再生，通常再生两次。每次再生后，通过测定类风湿关节炎血凝试验的柱前和柱后血浆效价，发现吸附剂的吸附能力得到了提高。
