Takahashi K, Yoshinoya S, Yoshizawa H, Miyamoto T
Blood Transfusion Service, University of Tokyo, Japan.
Clin Rheumatol. 1987 Dec;6(4):553-63. doi: 10.1007/BF02330593.
We developed a new adsorbent utilizing hydrophobic amino acids in order to treat severe rheumatoid arthritis patients with extracorporeal adsorption therapy. In in vitro experiment, the new adsorbent selectively removed immune complexes and rheumatoid factors from RA plasma presumably due to hydrophobic adsorption. Six out of eleven patients markedly improved in clinical as well as laboratory parameters of disease activities, particularly in their extra-articular manifestations. We recommend preferential use of this treatment since it can spare the replacement protein solution and is expected to give similar efficacy to simple plasma exchange therapy.
我们开发了一种利用疏水氨基酸的新型吸附剂，用于通过体外吸附疗法治疗重症类风湿性关节炎患者。在体外实验中，这种新型吸附剂可能由于疏水吸附作用而从类风湿性关节炎患者的血浆中选择性去除免疫复合物和类风湿因子。11名患者中有6名在疾病活动的临床和实验室参数方面有显著改善，尤其是在关节外表现方面。我们建议优先使用这种治疗方法，因为它可以节省替代蛋白溶液，并且有望产生与单纯血浆置换疗法相似的疗效。
