Graduate Program in Health and Development in the Central-West Region of Brazil, Medical School, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Mato Grosso do Sul, Brazil.
Biologist, Hematology Laboratory, State Secretariat of Health of Mato Grosso do Sul, Campo Grande 79084-180, Mato Grosso do Sul, Brazil.
Molecules. 2020 Nov 30;25(23):5630. doi: 10.3390/molecules25235630.
During pregnancy, women undergo metabolic and physiological changes, and their needs are higher, to maintain growth and development of the fetus. If the nutritional status of the expectant mother is not satisfactory, some maternal and neonatal complications can occur. In the second and third trimester of pregnancy, there is a reserve of nutrients in the fetus that can be utilized after birth; thereby, children present an accelerated growth in the first years of life, which is a proven response to the available nutrition pattern. However, if such a pattern is insufficient, there will be deficits during development, including brain function. Therefore, despite many recent published works about gestational nutrition, uncertainties still remain on the mechanisms of absorption, distribution, and excretion of micronutrients. Further elucidation is needed to better understand the impacts caused either by deficiency or excess of some micronutrients. Thus, to illustrate the contributions of minerals during prenatal development and in children, iodine, selenium, iron, zinc, calcium, and magnesium were selected. Our study sought to review the consequences related to gestational deficiency of the referred minerals and their impact on growth and development in children born from mothers with such deficiencies.
在妊娠期间,女性会经历代谢和生理变化,她们的需求更高,以维持胎儿的生长和发育。如果孕妇的营养状况不理想,可能会出现一些母婴并发症。在妊娠的第二和第三个三个月,胎儿会储备一些可以在出生后利用的营养物质;因此,儿童在生命的头几年会加速生长,这是对可用营养模式的一种已证实的反应。然而,如果这种模式不足,在发育过程中就会出现营养不足,包括大脑功能。因此,尽管最近发表了许多关于妊娠期营养的作品,但对于微量营养素的吸收、分布和排泄机制仍存在不确定性。需要进一步阐明,以更好地了解某些微量营养素缺乏或过量所造成的影响。因此,为了说明矿物质在胎儿发育和儿童期的作用,选择了碘、硒、铁、锌、钙和镁。我们的研究旨在综述妊娠期缺乏上述矿物质的相关后果,以及它们对母亲缺乏这些矿物质所生儿童的生长和发育的影响。