Obstetrics and Gynecology Department, Farwaniya Hospital, Sabah Al Nasser, Kuwait.
Paediatric Department, Farwaniya Hospital, Sabah Al Nasser, Kuwait.
BMC Pregnancy Childbirth. 2020 Dec 2;20(1):754. doi: 10.1186/s12884-020-03461-2.
The effect of SARS-CoV-2 infection in pregnant women and newborns is incompletely understood. Preliminary data shows a rather fluctuating course of the disease from asymptomatic or mild symptoms to maternal death. However, it is not clear whether the disease increases the risk of pregnancy-related complications. The aim of the study is to describe the maternal and neonatal clinical characteristics and outcome of pregnancies with SARS-CoV-2 infection.
In this retrospective national-based study, we analyzed the medical records of all pregnant women infected with SARS-CoV-2 and their neonates who were admitted to New-Jahra Hospital (NJH), Kuwait, between March 15th 2020 and May 31st 2020. During the study period and as part of the public health measures, a total of 185 pregnant women infected with SARS-CoV-2, regardless of symptoms, were hospitalized at NJH, and were included. Maternal and neonatal clinical manifestations, laboratory tests and treatments were collected. The outcomes of pregnancies included miscarriage, intrauterine fetal death (IUFD), preterm birth and live birth were assessed until the end date of the outcomes follow-up (November 10th 2020).
A total of 185 pregnant women infected with SARS-CoV-2 were enrolled with a median age of 31 years (interquartile range, IQR: 27.5-34), and median gestational age at diagnosis of SARS-CoV2 infection was 29 weeks (IQR: 18-34). The majority (88%) of these women had mild symptoms, with fever (58%) being the most common presenting symptom followed by cough (50.6%). At the time of the analysis, out of the 185, 3 (1.6%) of the pregnant women had a miscarriage, 1 (0.54%) had IUFD which was not related to COVID-19, 16 (8.6%) had ongoing pregnancies and 165 (89%) had a live birth. Only 2 (1.1%) of these women developed severe pneumonia and required intensive care. A total of 167 neonates with two sets of twins were born with median gestational age at birth was 38 (IQR: 36-39) weeks. Most of the neonates were asymptomatic, and only 2 of them tested positive on day 5 by nasopharyngeal swab testing.
In this national-based study, most of the pregnant women infected with SARS-CoV-2 showed mild symptoms. Although mother-to-child vertical transmission of SARS-CoV-2 is possible, COVID-19 infection during pregnancy may not lead to unfavorable maternal and neonatal outcomes.
SARS-CoV-2 感染孕妇和新生儿的影响尚不完全清楚。初步数据显示，疾病的病程从无症状或轻症到产妇死亡变化较大。然而，目前尚不清楚疾病是否会增加与妊娠相关的并发症的风险。本研究旨在描述 SARS-CoV-2 感染孕妇和新生儿的临床特征和结局。
本回顾性全国性研究纳入了 2020 年 3 月 15 日至 2020 年 5 月 31 日期间在科威特新贾赫拉医院（NJH）住院的所有感染 SARS-CoV-2 的孕妇及其新生儿的病历资料。在研究期间，作为公共卫生措施的一部分，共有 185 名无论症状如何均感染 SARS-CoV-2 的孕妇在 NJH 住院，并被纳入研究。收集了产妇和新生儿的临床表现、实验室检查和治疗情况。妊娠结局包括流产、宫内胎儿死亡（IUFD）、早产和活产，直至结局随访结束日期（2020 年 11 月 10 日）。
共纳入 185 名感染 SARS-CoV-2 的孕妇，中位年龄为 31 岁（四分位距，IQR：27.5-34），诊断 SARS-CoV-2 感染时的中位孕龄为 29 周（IQR：18-34）。这些孕妇中大多数（88%）症状较轻，发热（58%）是最常见的首发症状，其次是咳嗽（50.6%）。在分析时，185 名孕妇中有 3 名（1.6%）流产，1 名（0.54%）发生与 COVID-19 无关的 IUFD，16 名（8.6%）继续妊娠，165 名（89%）活产。仅有 2 名（1.1%）孕妇发展为严重肺炎，需要重症监护。共分娩了 167 名新生儿，其中包括 2 对双胞胎，中位胎龄为 38 周（IQR：36-39）周。大多数新生儿无症状，仅有 2 名新生儿在第 5 天通过鼻咽拭子检测呈阳性。
在这项全国性研究中，大多数感染 SARS-CoV-2 的孕妇表现为轻症。虽然 SARS-CoV-2 可能会垂直传播给胎儿，但 COVID-19 感染在妊娠期间可能不会导致母婴不良结局。
