Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; The Affiliated Hospital, Jiangsu University, Zhenjiang, Jiangsu 212001, China.
The Affiliated Hospital, Jiangsu University, Zhenjiang, Jiangsu 212001, China.
Trends Biochem Sci. 2021 Mar;46(3):213-224. doi: 10.1016/j.tibs.2020.09.008. Epub 2020 Oct 22.
Poly(β-L-malic acid) (PMLA) is a natural polyester produced by numerous microorganisms. Regarding its biosynthetic machinery, a nonribosomal peptide synthetase (NRPS) is proposed to direct polymerization of L-malic acid in vivo. Chemically versatile and biologically compatible, PMLA can be used as an ideal carrier for several molecules, including nucleotides, proteins, chemotherapeutic drugs, and imaging agents, and can deliver multimodal theranostics through biological barriers such as the blood-brain barrier. We focus on PMLA biosynthesis in microorganisms, summarize the physicochemical and physiochemical characteristics of PMLA as a naturally derived polymeric delivery platform at nanoscale, and highlight the attachment of functional groups to enhance cancer detection and treatment.
聚（β- L -苹果酸）（PMLA）是一种由许多微生物产生的天然聚酯。关于其生物合成机制，有人提出非核糖体肽合成酶（NRPS）在体内直接指导 L -苹果酸的聚合。PMLA 具有化学多功能性和生物相容性，可用作包括核苷酸、蛋白质、化疗药物和成像剂等多种分子的理想载体，并可通过血脑屏障等生物屏障传递多模态治疗。我们专注于微生物中的 PMLA 生物合成，总结了 PMLA 作为纳米级天然衍生聚合物递送平台的物理化学和理化特性，并强调了通过附着功能基团来增强癌症检测和治疗。
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