Division for Health Service Promotion, The University of Tokyo.
Department of Cardio-Diabetes Medicine, Tokushima University Graduate School of Biomedical Sciences.
Circ J. 2020 Dec 25;85(1):2-8. doi: 10.1253/circj.CJ-20-0935. Epub 2020 Dec 1.
Adipose tissue serves not only as an energy store or a mechanical cushion, but also as an endocrine organ. Recent evidence revealed that perivascular adipose tissue is involved in vascular homeostasis and pathophysiology of adjacent arteries by producing various adipokines. Epicardial adipose tissue (EAT) is located between the surface of the heart and the visceral layer of the pericardium and surrounds the coronary arteries. Many clinical studies suggest that an increase in EAT volume is associated with coronary artery disease. It has been reported that exercise and some antidiabetic drugs can reduce EAT volume. In this review, we outline recent findings on the roles of EAT in the pathogenesis of coronary atherosclerosis.
脂肪组织不仅是能量储存器或机械缓冲器，还是内分泌器官。最近的证据表明，血管周围脂肪组织通过产生各种脂肪因子参与相邻动脉的血管稳态和病理生理学。心外膜脂肪组织（EAT）位于心脏表面和心包脏层之间，环绕冠状动脉。许多临床研究表明，EAT 体积的增加与冠状动脉疾病有关。据报道，运动和一些抗糖尿病药物可以减少 EAT 体积。在这篇综述中，我们概述了 EAT 在冠状动脉粥样硬化发病机制中的作用的最新发现。
