Division of Pharmacodynamics, Keio University Faculty of Pharmacy.
Biol Pharm Bull. 2020;43(12):1815-1822. doi: 10.1248/bpb.b20-00668.
Blood transport proteins are biogenic molecules with unique and interesting inherent characteristics that make up living organisms. As the utilization of their inherent characteristics can be a groundbreaking strategy to resolve and improve several clinical problems, attempts have been made to develop pharmaceutical and biomedical preparations based on blood transport proteins for the treatment and diagnosis of disorders. Among various blood transport proteins, we focus on the immense potential of hemoglobin and albumin to serve as carriers of biomedical gases (oxygen and carbon monoxide) and anticancer agents (low-molecular compounds and antisense oligodeoxynucleotides), respectively, for the development of innovative drug delivery systems (DDS) to treat intractable disorders and solid cancers. In this review, I introduce the pharmaceutical technology, strategies, and application of DDS carriers that have been designed on the basis of the structure and function of hemoglobin and albumin. In addition, the prospect of using hemoglobin and albumin as materials for DDS carriers is discussed.
血液转运蛋白是具有独特而有趣固有特性的生物分子，构成了生物体。由于利用其固有特性可以成为解决和改善多种临床问题的开创性策略，因此人们尝试基于血液转运蛋白开发用于治疗和诊断疾病的药物和生物医学制剂。在各种血液转运蛋白中，我们专注于血红蛋白和白蛋白作为生物医学气体（氧气和一氧化碳）和抗癌剂（低分子化合物和反义寡脱氧核苷酸）载体的巨大潜力，分别用于开发创新药物输送系统（DDS）以治疗难治性疾病和实体瘤。在这篇综述中，我介绍了基于血红蛋白和白蛋白的结构和功能设计的 DDS 载体的制药技术、策略和应用。此外，还讨论了使用血红蛋白和白蛋白作为 DDS 载体材料的前景。
