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子宫内膜异位症:三级护理医院的临床病理研究

Endometriosis: A Clinicopathological Study in a Tertiary Care Hospital.

作者信息

Bhat Shubha P, Kaliyat Sajitha, Laxminarayana Kishan Prasad Hosapatna, Srinivas Teerthanath, Venugopala Krishna Prasad Holalkere, Shetty Jayaprakash Kubalady

机构信息

Department of Pathology, K.S Hegde Medical Academy, Nitte-Deemed to be University, Mangalore, Karnataka, India.

出版信息

J Lab Physicians. 2020 Dec;12(3):184-190. doi: 10.1055/s-0040-1720946. Epub 2020 Nov 23.

DOI:10.1055/s-0040-1720946
PMID:33268936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7684995/
Abstract

Endometriosis (EM) is an estrogen-dependent disease characterized by the presence of endometrial gland and stroma outside the uterus. It is commonly seen in the reproductive age group and is a leading cause of infertility. Patients present with chronic pelvic pain, menstrual abnormalities, dyspareunia, or mass per abdomen. Surgical excision is the treatment of choice with postoperative medications and progesterone agents.  This study aims at determining the distribution of EM in terms of age, parity, symptoms, site, morphological features. We also analyzed the management of EM in these cases.  This is a retrospective study done in a tertiary care hospital in Mangalore, India. The case records of 77 histopathologically confirmed cases of EM during the 7 years between June 2012 and May 2019 were studied. Demographic profiles, parity, presenting complaints, site of the lesion, morphological features, treatment given, follow-up, and recurrence were noted and analyzed.  Of the 77 patients with EM, the most common age group was the fourth decade (40%). The majority (31, 40.25%) of the patients in this study were nulliparous. Chronic pelvic pain was the most common symptom. The most frequent site was ovary.  The most frequent site of EM is ovary, leading to infertility. With the advent of laparoscopy, early diagnosis and excision have been feasible. The histopathological examination should be done for confirmation. Awareness of this disease among health care professionals is necessary whenever a woman in reproductive age presents with chronic pelvic pain and infertility.

摘要

子宫内膜异位症(EM)是一种雌激素依赖性疾病,其特征是子宫外存在子宫内膜腺体和间质。它常见于育龄期女性,是导致不孕的主要原因之一。患者表现为慢性盆腔疼痛、月经异常、性交困难或腹部肿块。手术切除是首选治疗方法,术后需配合药物和孕激素制剂。 本研究旨在确定子宫内膜异位症在年龄、产次、症状、部位、形态特征方面的分布情况。我们还分析了这些病例中子宫内膜异位症的治疗方法。 这是一项在印度芒格洛尔一家三级护理医院进行的回顾性研究。对2012年6月至2019年5月这7年间77例经组织病理学确诊的子宫内膜异位症病例记录进行了研究。记录并分析了患者的人口统计学资料、产次、主诉、病变部位、形态特征、治疗方法、随访情况及复发情况。 在77例子宫内膜异位症患者中,最常见的年龄组是40岁左右(占40%)。本研究中的大多数患者(31例,占40.25%)未生育。慢性盆腔疼痛是最常见的症状。最常发生的部位是卵巢。 子宫内膜异位症最常发生的部位是卵巢,可导致不孕。随着腹腔镜检查的出现,早期诊断和切除已成为可能。需进行组织病理学检查以确诊。每当育龄期女性出现慢性盆腔疼痛和不孕时,医护人员都有必要了解这种疾病。

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本文引用的文献

1
Thoracic Endometriosis Syndrome: A Veritable Pandora's Box.胸腔子宫内膜异位症综合征:一个名副其实的潘多拉魔盒。
J Clin Diagn Res. 2016 Apr;10(4):QR04-8. doi: 10.7860/JCDR/2016/17668.7700. Epub 2016 Apr 1.
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Prevalence; Characteristics and Management of Endometriosis Amongst Infertile Women: A One Year Retrospective Study.不孕女性子宫内膜异位症的患病率、特征及管理:一项为期一年的回顾性研究
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Thoracic endometriosis syndrome: case report and review of the literature.
胸腔子宫内膜异位症综合征:病例报告及文献综述
Perm J. 2014 Summer;18(3):61-5. doi: 10.7812/TPP/13-154.
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Endometriosis: a life cycle approach?子宫内膜异位症:生命周期方法?
Am J Obstet Gynecol. 2013 Oct;209(4):307-16. doi: 10.1016/j.ajog.2013.03.009. Epub 2013 Mar 15.
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Stem cells: are they the answer to the puzzling etiology of endometriosis?干细胞:它们是否能解答子宫内膜异位症病因学之谜?
Histol Histopathol. 2012 Jan;27(1):23-9. doi: 10.14670/HH-27.23.
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Endometriosis of the appendix: Report of three cases.阑尾子宫内膜异位症:三例报告
Int J Surg Case Rep. 2011;2(2):16-9. doi: 10.1016/j.ijscr.2010.11.001. Epub 2010 Nov 20.
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Endometriosis - morphology, clinical presentations and molecular pathology.子宫内膜异位症——形态学、临床表现及分子病理学
J Lab Physicians. 2010 Jan;2(1):1-9. doi: 10.4103/0974-2727.66699.
8
Plasticity of human menstrual blood stem cells derived from the endometrium.人子宫内膜来源经血干细胞的可塑性。
J Zhejiang Univ Sci B. 2011 May;12(5):372-80. doi: 10.1631/jzus.B1100015.
9
Endometriosis and the adolescent.子宫内膜异位症与青少年
Clin Obstet Gynecol. 2010 Jun;53(2):420-8. doi: 10.1097/GRF.0b013e3181dbdc61.
10
Endometriosis, assisted reproduction technology, and risk of adverse pregnancy outcome.子宫内膜异位症、辅助生殖技术与不良妊娠结局风险
Hum Reprod. 2009 Sep;24(9):2341-7. doi: 10.1093/humrep/dep186. Epub 2009 May 12.