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as a potential future drug molecule for COVID-19.作为一种未来可能用于治疗新冠肺炎的药物分子。
Future Drug Discov. 2020 Oct 1;2(4):FDD50. doi: 10.4155/fdd-2020-0024.
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(L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy.(L.) Dunal（冬氨酸）在 SARS-CoV-2 感染的可能治疗和临床管理中的应用：基于植物的药物发现和靶向治疗。
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Withanone from Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model.Withanone 抑制 SARS-CoV-2 RBD 与宿主 ACE2 的相互作用，挽救人源化斑马鱼模型中 Spike 蛋白诱导的病理损伤。
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Phytochemicals of as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery.作为一种未来有望对抗新型冠状病毒的药物的植物化学物质：药理作用、分子机制、分子对接评估及高效递送
Microorganisms. 2023 Apr 12;11(4):1000. doi: 10.3390/microorganisms11041000.
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Identification of bioactive molecule from (Ashwagandha) as SARS-CoV-2 main protease inhibitor.从 （印度人参）中鉴定出生物活性分子作为 SARS-CoV-2 主蛋白酶抑制剂。
J Biomol Struct Dyn. 2021 Sep;39(15):5668-5681. doi: 10.1080/07391102.2020.1790425. Epub 2020 Jul 8.
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Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants - (Ashwagandha), (Giloy) and (Tulsi) - a molecular docking study.通过阿育吠陀药用植物（ Ashwagandha ）、（ Giloy ）和（ Tulsi ）的活性植物化学成分靶向 COVID-19 （ SARS-CoV-2 ）主蛋白酶 - （ Ashwagandha ）、（ Giloy ）和（ Tulsi ） - 分子对接研究。
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Withasomniferol C, a new potential SARS-CoV-2 main protease inhibitor from the plant proposed by approaches.利用植物中的马鞭草新苷 C，提出了一种新型潜在的 SARS-CoV-2 主要蛋白酶抑制剂。
PeerJ. 2022 Jun 2;10:e13374. doi: 10.7717/peerj.13374. eCollection 2022.
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The Natural Products Withaferin A and Withanone from the Medicinal Herb Are Covalent Inhibitors of the SARS-CoV-2 Main Protease.药用植物醉茄中的天然产物醉茄内酯 A 和醉茄内脂是 SARS-CoV-2 主蛋白酶的共价抑制剂。
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and studies on inhibitors for SARS-CoV-2 non-structural proteins with dual herbal combination of with five rasayana herbs.以及具有双重草药组合的 SARS-CoV-2 非结构蛋白抑制剂的研究，该组合包括五种延年益寿草药。
J Biomol Struct Dyn. 2023 May;41(8):3265-3280. doi: 10.1080/07391102.2022.2046642. Epub 2022 Mar 8.

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Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection.睡茄内酯A抑制基孔肯雅病毒nsP2蛋白酶，并在病毒感染的细胞培养和小鼠模型中显示出抗病毒活性。
PLoS Pathog. 2024 Dec 30;20(12):e1012816. doi: 10.1371/journal.ppat.1012816. eCollection 2024 Dec.
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Phytochemical analysis of and and their therapeutic activities with special reference to COVID-19.[植物名称1]和[植物名称2]的植物化学分析及其治疗活性，特别提及对COVID-19的作用
World J Exp Med. 2024 Sep 20;14(3):95512. doi: 10.5493/wjem.v14.i3.95512.
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Steroidal lactones from effectively target Beta, Gamma, Delta and Omicron variants of SARS-CoV-2 and reveal a decreased susceptibility to viral infection and perpetuation: a polypharmacology approach.来自[具体来源未明确]的甾体内酯有效靶向严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的β、γ、δ和奥密克戎变体，并显示出对病毒感染和持续存在的易感性降低：一种多药理学方法。
In Silico Pharmacol. 2024 Feb 27;12(1):14. doi: 10.1007/s40203-023-00184-y. eCollection 2024.
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Fighting cytokine storm and immunomodulatory deficiency: By using natural products therapy up to now.对抗细胞因子风暴和免疫调节缺陷：截至目前采用天然产物疗法。
Front Pharmacol. 2023 Apr 12;14:1111329. doi: 10.3389/fphar.2023.1111329. eCollection 2023.
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Phytochemicals of as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery.作为一种未来有望对抗新型冠状病毒的药物的植物化学物质：药理作用、分子机制、分子对接评估及高效递送
Microorganisms. 2023 Apr 12;11(4):1000. doi: 10.3390/microorganisms11041000.
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The immunomodulatory role of (L.) dunal in inflammatory diseases.（L.）dunal在炎症性疾病中的免疫调节作用。
Front Pharmacol. 2023 Feb 22;14:1084757. doi: 10.3389/fphar.2023.1084757. eCollection 2023.
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(L.) Dunal (Ashwagandha); current understanding and future prospect as a potential drug candidate.（L.）杜纳尔（印度人参）；作为潜在候选药物的当前认识与未来前景
Front Pharmacol. 2022 Dec 12;13:1029123. doi: 10.3389/fphar.2022.1029123. eCollection 2022.
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Stem cell therapy: a novel approach against emerging and re-emerging viral infections with special reference to SARS-CoV-2.干细胞治疗：一种针对新发和再发病毒感染的新方法，特别针对 SARS-CoV-2。
Mol Biol Rep. 2023 Mar;50(3):2663-2683. doi: 10.1007/s11033-022-07957-2. Epub 2022 Dec 19.
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Efficacy of add-on Ayurveda and Yoga intervention in health care workers of tertiary care hospital during COVID-19: Randomized controlled trial.阿育吠陀和瑜伽辅助干预对三级护理医院医护人员在2019年冠状病毒病期间的疗效：随机对照试验
Complement Ther Clin Pract. 2022 Aug;48:101601. doi: 10.1016/j.ctcp.2022.101601. Epub 2022 May 8.
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In silico, screening of plant extracts for anti-SARS-CoV-2 activity and evaluation of their acute and sub-acute toxicity.在计算机上筛选植物提取物的抗SARS-CoV-2活性并评估其急性和亚急性毒性。
Phytomed Plus. 2022 May;2(2):100233. doi: 10.1016/j.phyplu.2022.100233. Epub 2022 Jan 31.

本文引用的文献

1
Withaferin A: a potential therapeutic agent against COVID-19 infection.醉茄素 A：一种对抗 COVID-19 感染的潜在治疗药物。
J Ovarian Res. 2020 Jul 19;13(1):79. doi: 10.1186/s13048-020-00684-x.
2
Identification of bioactive molecule from (Ashwagandha) as SARS-CoV-2 main protease inhibitor.从 （印度人参）中鉴定出生物活性分子作为 SARS-CoV-2 主蛋白酶抑制剂。
J Biomol Struct Dyn. 2021 Sep;39(15):5668-5681. doi: 10.1080/07391102.2020.1790425. Epub 2020 Jul 8.
3
Sars-cov-2 host entry and replication inhibitors from Indian ginseng: an approach.从印度人参中寻找 SARS-CoV-2 宿主进入和复制抑制剂：一种方法。
J Biomol Struct Dyn. 2021 Aug;39(12):4510-4521. doi: 10.1080/07391102.2020.1778539. Epub 2020 Jun 22.
4
Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells.化合物 Withaone 和 Withaferin-A 被预测能够与跨膜丝氨酸蛋白酶 2（TMPRSS2）相互作用，从而阻止 SARS-CoV-2 进入细胞。
J Biomol Struct Dyn. 2022 Jan;40(1):1-13. doi: 10.1080/07391102.2020.1775704. Epub 2020 Jun 16.
5
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2.COVID-19 中的免疫反应：通过靶向 SARS-CoV-2 触发的途径来应对药理学挑战。
Signal Transduct Target Ther. 2020 May 29;5(1):84. doi: 10.1038/s41392-020-0191-1.
6
Identification of phytochemical inhibitors against main protease of COVID-19 using molecular modeling approaches.使用分子建模方法鉴定针对新冠病毒主要蛋白酶的植物化学抑制剂。
J Biomol Struct Dyn. 2021 Jul;39(10):3760-3770. doi: 10.1080/07391102.2020.1772112. Epub 2020 Jun 4.
7
Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (M) of SARS-CoV-2 and inhibit its activity.化合物 Withaone 和咖啡酸苯乙酯被预测可与 SARS-CoV-2 的主要蛋白酶（M）相互作用并抑制其活性。
J Biomol Struct Dyn. 2021 Jul;39(11):3842-3854. doi: 10.1080/07391102.2020.1772108. Epub 2020 Jun 1.
8
COVID-19 and nicotine as a mediator of ACE-2.新型冠状病毒肺炎与尼古丁作为 ACE-2 的中介
Eur Respir J. 2020 Jun 4;55(6). doi: 10.1183/13993003.01261-2020. Print 2020 Jun.
9
High synergistic antibacterial, antibiofilm, antidiabetic and antimetabolic activity of Withania somnifera leaf extract-assisted zinc oxide nanoparticle.印度萝芙木叶提取物辅助氧化锌纳米粒子具有高效协同的抗菌、抗生物膜、抗糖尿病和抗代谢活性。
Bioprocess Biosyst Eng. 2020 Sep;43(9):1533-1547. doi: 10.1007/s00449-020-02346-0. Epub 2020 Apr 16.
10
COVID-19: A promising cure for the global panic.COVID-19：全球恐慌的有希望的治愈方法。
Sci Total Environ. 2020 Jul 10;725:138277. doi: 10.1016/j.scitotenv.2020.138277. Epub 2020 Apr 4.

as a potential future drug molecule for COVID-19.

作者信息

Kashyap Vivek K, Dhasmana Anupam, Yallapu Murali M, Chauhan Subhash C, Jaggi Meena

机构信息

Department of Immunology & Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX 78504, USA.

South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.

出版信息

Future Drug Discov. 2020 Oct 1;2(4):FDD50. doi: 10.4155/fdd-2020-0024.

DOI:10.4155/fdd-2020-0024
PMID:33269342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7702281/
Abstract
摘要