Department of Clinical Immunology and Rheumatology, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, India.
Mod Rheumatol Case Rep. 2021 Jan;5(1):113-116. doi: 10.1080/24725625.2020.1785075. Epub 2020 Jul 3.
Granulomatosis with polyangiitis (GPA) is a rare multisystem autoimmune disease of unknown aetiology with only a few reported cases about spinal cord involvement in the literature. We report on the case of an established GPA presented with acute onset bilateral lower limb weakness, urinary retention and faecal incontinence consistent with transverse myelitis. Contrast-enhanced MRI scanning revealed T2 hyperintensity extending from the T1 to conus medularis, without any gadolinium enhancement features suggestive of long segment myelitis. He was successfully treated with I.V IG followed by Rituximab.
肉芽肿伴多血管炎（GPA）是一种罕见的多系统自身免疫性疾病，病因不明，文献中仅有少数关于脊髓受累的报道。我们报告了一例确诊的 GPA 病例，其表现为急性发作的双侧下肢无力、尿潴留和大便失禁，符合横贯性脊髓炎的特征。增强 MRI 扫描显示 T2 高信号从 T1 延伸至圆锥，没有任何钆增强特征提示长节段脊髓炎。他成功地接受了静脉注射免疫球蛋白（IVIG）联合利妥昔单抗治疗。
