Khan Raheel, Kulasiri Don, Samarasinghe Sandhya
Centre for Advanced Computational Solutions (C-fACS), Lincoln University; Department of Molecular Biosciences, Lincoln University, Christchurch, New Zealand.
Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand.
Neural Regen Res. 2021 Jun;16(6):1150-1157. doi: 10.4103/1673-5374.300331.
Protein phosphorylation and dephosphorylation are two essential and vital cellular mechanisms that regulate many receptors and enzymes through kinases and phosphatases. Ca- dependent kinases and phosphatases are responsible for controlling neuronal processing; balance is achieved through opposition. During molecular mechanisms of learning and memory, kinases generally modulate positively while phosphatases modulate negatively. This review outlines some of the critical physiological and structural aspects of kinases and phosphatases involved in maintaining postsynaptic structural plasticity. It also explores the link between neuronal disorders and the deregulation of phosphatases and kinases.
蛋白质磷酸化和去磷酸化是两种重要且关键的细胞机制，它们通过激酶和磷酸酶调节许多受体和酶。钙依赖性激酶和磷酸酶负责控制神经元活动；通过相互拮抗实现平衡。在学习和记忆的分子机制中，激酶通常起正向调节作用，而磷酸酶起负向调节作用。本综述概述了参与维持突触后结构可塑性的激酶和磷酸酶的一些关键生理和结构方面。它还探讨了神经元疾病与磷酸酶和激酶失调之间的联系。
