Song Yang-Yang, Xu Wen-Tao, Ni Guang-Xia
School of Acupuncture and Tuina, School of Regimen and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing 210029, China.
Zhen Ci Yan Jiu. 2020 Nov 25;45(11):941-4. doi: 10.13702/j.1000-0607.200045.
Axon guidance cues includes Slit, Semaphorin, Ephrin and Netrin. They have the function of regulating the regeneration of axons and guiding the regenerated axons to the correct target. They can affect the nervous system, cardiovascular system, and participate in the proliferation and migration of tumor cells. The current research on the influence of acupuncture and moxibustion(mainly focusing on electroacupuncture) on axon guidance cues is limited to animal experiments. Electroacupuncture can treat diseases dominated by the nervous system by regulating the expression of axon guidance cues. This review summarizes the research progress of acupuncture and moxibustion on regulating axonal guidance cues, is hoped to provide references for the mechanism of acupuncture and moxibustion in treating nervous system disease and ideas for acupuncture treatment of diseases related to axon guidance cues.
轴突导向因子包括Slit、信号素、 Ephrin和网蛋白。它们具有调节轴突再生并引导再生轴突到达正确靶点的功能。它们可影响神经系统、心血管系统，并参与肿瘤细胞的增殖和迁移。目前关于针灸（主要是电针）对轴突导向因子影响的研究仅限于动物实验。电针可通过调节轴突导向因子的表达来治疗以神经系统为主的疾病。本综述总结了针灸在调节轴突导向因子方面的研究进展，希望为针灸治疗神经系统疾病的机制提供参考，并为针灸治疗与轴突导向因子相关疾病提供思路。
