Department of Pharmacy Practice, Faculty of Pharmacy, Vignan Institute of Pharmaceutical Technology, Visakhapatnam, India.
Patient Experience Management, Research Specialist, Forum Business Research, Visakhapatnam, India.
Prague Med Rep. 2020;121(4):267-276. doi: 10.14712/23362936.2020.24.
Tubercular mastitis is a rare form of extrapulmonary tuberculosis commonly seen in multiparous and lactating women in developing countries. It is a diagnostic challenge and commonly misdiagnosed as breast carcinoma. Tubercular mastitis is paucibacillary, and fine-needle aspiration cytology provides an accurate diagnosis - the presence of granulomas with Langerhans giant cells on histopathological examination warrants empirical treatment with anti-tubercular drugs. We report a case of a 31-year-old Indian female who consulted a local physician with chief complaints of a palpable, tender mass in her left breast, with pain, swelling, and purulent discharge past 15 days. The patient's past medical, surgical, medication history, and family history (concerning tuberculosis) were not significant. Initially, the patient suspected of breast malignancy based upon physical examination, mammography, and fine-needle aspiration cytology but an accurate diagnosis of tubercular mastitis made with repeated histopathological examination. Histopathologic examination of excised material showed granulomas composed of histocytes, Langerhans giant cells, and inflammatory cells. The patient underwent surgical drainage on the left breast and put on the anti-tubercular regimen for 6 months with her child also prescribed isoniazid for 6 months. The patient advised for regular follow-ups.
结核性乳腺炎是一种罕见的肺外结核形式,常见于发展中国家的多产妇和哺乳期妇女。它是一种诊断挑战,常被误诊为乳腺癌。结核性乳腺炎是少菌性的,细针抽吸细胞学检查可提供准确的诊断-组织病理学检查显示存在肉芽肿和朗格汉斯巨细胞,可凭经验用抗结核药物进行治疗。我们报告了一例 31 岁的印度女性,她因左乳房可触及的触痛性肿块,伴有疼痛、肿胀和脓性分泌物 15 天而就诊于当地医生。患者的既往内科、外科、用药史和家族史(关于结核病)均无明显异常。最初,根据体格检查、乳房 X 线摄影和细针抽吸细胞学检查怀疑为乳腺癌,但通过反复组织病理学检查准确诊断为结核性乳腺炎。切除物的组织病理学检查显示由组织细胞、朗格汉斯巨细胞和炎症细胞组成的肉芽肿。患者在左乳房接受了手术引流,并接受了 6 个月的抗结核治疗,其孩子也接受了 6 个月的异烟肼治疗。建议患者定期随访。