Cell and Tissue Bank, Centro de Transfusión de la Comunidad Valenciana, Valencia, Spain.
Transplant Coordination Unit, Consorcio Hospital General Universitario, Valencia, Spain.
Transpl Infect Dis. 2021 Jun;23(3):e13535. doi: 10.1111/tid.13535. Epub 2020 Dec 14.
Standards on tissue banking determine the need of microbiological monitoring during critical steps (recovery, processing, storage, and transplantation). This information will be useful for both discarding contaminated tissues or risk analysis (in case of recipient infection). In this study, we show the case of a multiorgan-multitissue donor colonized by Candida auris. This microorganism is characterized by multidrug resistance, with higher transmissibility and severe outcome. Some of the microbiological cultures from arteries tested positive for this microorganism, but it was not cultured in samples from musculoskeletal tissues and corneas. No recipient case of infection transmission by Candida species was observed (organs and cornea). The implementation of active surveillance protocol for C. auris detection in critical care units (as source of tissue donors) has been suggested as a part of our hospitals' infection control policy.
组织库标准确定了在关键步骤（复苏、处理、储存和移植）中进行微生物监测的必要性。这些信息对于丢弃受污染的组织或风险分析（在受者感染的情况下）都非常有用。在本研究中，我们展示了一例由耳念珠菌定植的多器官-多组织供者的案例。这种微生物具有多药耐药性，传染性更高，后果更严重。一些来自动脉的微生物培养物对这种微生物呈阳性，但在肌肉骨骼组织和角膜的样本中未培养出这种微生物。未观察到受者通过念珠菌属传播感染的病例（器官和角膜）。建议在重症监护病房（作为组织供者的来源）实施主动监测方案以检测耳念珠菌，作为我们医院感染控制政策的一部分。
