Cell and Tissue Bank, Centro de Transfusión de la Comunidad Valenciana, Valencia, Spain.
Service of Microbiology, Consorcio Hospital General Universitario, Valencia, Spain.
J Hosp Infect. 2021 Jun;112:49-53. doi: 10.1016/j.jhin.2021.03.003. Epub 2021 Mar 9.
Microbiological contamination is one of the main risks that must be controlled in tissue banking practices. For this reason, strict donor selection criteria are applied, disinfection protocols are used, and microbiological monitoring is performed at various stages.
To detect Candida auris in arterial allografts and assess its origin.
Data on two multi-tissue donations with positive microbiological cultures for C. auris were analysed. Risk factors for microbiological contamination were assessed at procurement, processing and post storage.
C. auris was only isolated in cultures from arteries, and was not detected in cultures from cornea, musculoskeletal tissue or skin (even in the axillary-rectal sample taken from one donor).
The donor's own skin was identified as the most likely source to explain the contamination of arteries by C. auris. Due to the pathogenicity of this fungus and difficulties associated with its correct identification, the implementation of measures for its detection in tissue donations is recommended.
微生物污染是组织库实践中必须控制的主要风险之一。因此，适用严格的供体选择标准，使用消毒方案，并在各个阶段进行微生物监测。
检测动脉同种异体移植物中的耳念珠菌并评估其来源。
分析了两例微生物培养阳性的多组织供体的数据。在采集、处理和储存后评估了微生物污染的危险因素。
仅在动脉培养物中分离出耳念珠菌，在角膜、肌肉骨骼组织或皮肤的培养物中未检测到（即使在从一名供体采集的腋窝-直肠样本中也未检测到）。
供体自身的皮肤被认为是最有可能导致耳念珠菌污染动脉的原因。由于该真菌的致病性及其正确鉴定的困难，建议在组织供体中实施检测措施。
