Department of Neurology, Rambam Health Care Campus, Haifa, Israel.
Department of Neurology, Carmel Hospital, Haifa, Israel.
PLoS One. 2020 Dec 3;15(12):e0243142. doi: 10.1371/journal.pone.0243142. eCollection 2020.
Ischemic stroke is a widespread disease carrying high morbidity and mortality. Transesophageal echocardiography (TEE) is considered an important tool in the work-up of patients with acute ischemic stroke (AIS) and transient ischemic attack (TIA) patients; its utility is limited by a semi-invasive nature. The purpose of this study was to evaluate the probability of treatment change due to TEE findings (yield) in the work-up of AIS and TIA patients.
Retrospective data on patients with AIS or TIA who underwent TEE examination between 2000-2013 were collected from the institutional registry.
The average age of 1284 patients who were included in the study was 57±10.4, 66% of patients were male. The most frequent TEE findings included aortic plaques in 54% and patent foramen ovale (PFO) in 15%. TEE findings led to treatment change in 135 (10.5%) patients; anticoagulant treatment was initiated in 110 of them (81%). Most common etiology for switch to anticoagulation was aortic plaques (71 patients); PFO was second most common reason (26 patients). Significant TEE findings (thrombus, endocarditis, tumor) were found in 1.9% of patients, they were more common in young patients (<55; 56% of the patients).
The beginning of anticoagulation treatment in patients with thick and complicated plaques was found frequently in our study. Significant TEE findings, were infrequent, constituted an absolute indication for treatment change and were more common in younger patients.
缺血性脑卒中是一种广泛存在的疾病,具有较高的发病率和死亡率。经食管超声心动图(TEE)被认为是急性缺血性脑卒中(AIS)和短暂性脑缺血发作(TIA)患者检查的重要工具;但其应用受到半侵袭性的限制。本研究旨在评估 TEE 检查结果(检出率)在 AIS 和 TIA 患者检查中的改变治疗的可能性。
从机构注册处收集了 2000-2013 年间接受 TEE 检查的 AIS 或 TIA 患者的回顾性数据。
纳入研究的 1284 例患者的平均年龄为 57±10.4,66%为男性。最常见的 TEE 发现包括主动脉斑块(54%)和卵圆孔未闭(PFO)(15%)。TEE 检查结果导致 135 例(10.5%)患者治疗改变;其中 110 例(81%)开始抗凝治疗。转向抗凝治疗的最常见病因是主动脉斑块(71 例);其次是 PFO(26 例)。在 1.9%的患者中发现了有意义的 TEE 发现(血栓、心内膜炎、肿瘤),它们在年轻患者(<55 岁;患者的 56%)中更为常见。
在我们的研究中,经常发现有厚而复杂斑块的患者开始抗凝治疗。有意义的 TEE 发现并不常见,构成了改变治疗的绝对指征,并且在年轻患者中更为常见。