瑞典新生儿脑膜炎模式的变化。一项1976年与1983年的对比研究。

Changing pattern of neonatal meningitis in Sweden. A comparative study 1976 vs. 1983.

作者信息

Bennhagen R, Svenningsen N W, Békássy A N

机构信息

Department of Pediatrics, University Hospital, Lund, Sweden.

出版信息

Scand J Infect Dis. 1987;19(6):587-93. doi: 10.3109/00365548709117191.

DOI:10.3109/00365548709117191

PMID:3327148

Abstract

A nationwide retrospective epidemiological survey of neonatal meningitis in Sweden was performed in order to estimate possible changes in incidence, etiology and mortality. The total number of newborns with meningitis was 137 and 40 (29%) were preterm (less than 37 gestational weeks) infants and 27 of these preterm boys (20%). Meningitis from group B streptococci and Escherichia coli, the two major causative organisms in 1976, had decreased markedly in 1983. The identification rate of viral origin was more frequent during 1983 compared to 1976. The total incidence of meningitis was 8.9/10,000 livebirths in 1983 vs. 5.6/10,000 in 1976 but the rate of verified bacterial meningitis had decreased from 3.6/10,000 (1976) to 1.9/10,000 (1983). The total outcome was improved significantly since the combined mortality and handicap rates decreased from 34% in 1976 to 15% in 1983.

摘要

为了评估新生儿脑膜炎在发病率、病因及死亡率方面可能发生的变化，瑞典开展了一项全国性的新生儿脑膜炎回顾性流行病学调查。患脑膜炎的新生儿总数为137例，其中40例（29%）为早产儿（孕周小于37周），且这些早产儿中有27例为男婴（20%）。1976年导致脑膜炎的两大主要病原体——B族链球菌和大肠杆菌，在1983年时显著减少。与1976年相比，1983年病毒源性脑膜炎的确诊率更高。1983年脑膜炎的总发病率为8.9/10,000活产儿，而1976年为5.6/10,000，但确诊的细菌性脑膜炎发病率已从1976年的3.6/10,000降至1983年的1.9/10,000。由于死亡率和残疾率之和从1976年的34%降至1983年的15%，总体预后得到显著改善。