Lu Wen-Chi, Chuang Fu-Sheng, Venkatesan Manikandan, Cho Chia-Jung, Chen Po-Yun, Tzeng Yung-Ru, Yu Yang-Yen, Rwei Syang-Peng, Kuo Chi-Ching
Research and Development Center of Smart Textile Technology, Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei 10608, Taiwan.
Department of Applied Cosmetology, Lee-Ming Institute of Technology, New Taipei City 243083, Taiwan.
Polymers (Basel). 2020 Dec 1;12(12):2882. doi: 10.3390/polym12122882.
The development of nontoxic and biodegradable alginate-based materials has been a continual goal in biological applications. However, their hydrophilic nature and lack of spinnability impart water instability and poor mechanical strength to the nanofiber. To overcome these limitations, sodium alginate (SA) and waterborne polyurethane (WPU) were blended and crosslinked with calcium chloride; 30 wt % of SA exhibited good compatibility. Further addition of 10 wt % calcium chloride improved the water stability to an extremely humid region. Furthermore, the stress-strain curve revealed that the initial modulus and the elongation strength of the WPU/SA and WPU/CA blends increased with SA content, and the crosslinker concentration clearly indicated the dressing material hardness resulted from this simple blend strategy. The WPU/SA electrospun nanofibrous blend contained porous membranes; it exhibited good mechanical strength with water-stable, water-absorbable (37.5 wt %), and moisture-permeable (25.1 g/m-24 h) characteristics, suggesting our cost-effective material could function as an effective wound dressing material.
开发无毒且可生物降解的海藻酸盐基材料一直是生物应用领域的一个持续目标。然而，它们的亲水性以及缺乏可纺性赋予了纳米纤维水不稳定性和较差的机械强度。为克服这些局限性，将海藻酸钠（SA）与水性聚氨酯（WPU）混合并用氯化钙进行交联；30 wt%的SA表现出良好的相容性。进一步添加10 wt%的氯化钙可将水稳定性提高到极高湿度区域。此外，应力-应变曲线表明，WPU/SA和WPU/CA共混物的初始模量和拉伸强度随SA含量的增加而增加，交联剂浓度清楚地表明了这种简单共混策略导致的敷料材料硬度。WPU/SA电纺纳米纤维共混物包含多孔膜；它表现出良好的机械强度，具有水稳定、吸水（37.5 wt%）和透湿（25.1 g/m²·24 h）特性，这表明我们这种具有成本效益的材料可作为一种有效的伤口敷料材料。
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