Espinosa Eduardo, Filgueira Daniel, Rodríguez Alejandro, Chinga-Carrasco Gary
Chemical Engineering Department, Faculty of Science, Universidad de Córdoba, Building Marie-Curie, Campus de Rabanales, 14014 Córdoba, Spain.
RISE PFI, Høgskoleringen 6b, 7491 Trondheim, Norway.
Bioengineering (Basel). 2019 Jul 30;6(3):65. doi: 10.3390/bioengineering6030065.
2,2,6,6-tetramethylpyperidine-1-oxyl (TEMPO) oxidized cellulose nanofibrils (CNF) were used as ink for three-dimensional (3D) printing of porous structures with potential as wound dressings. Alginate (10, 20, 30 and 40 wt%) was incorporated into the formulation to facilitate the ionic cross-linking with calcium chloride (CaCl). The effect of two different concentrations of CaCl (50 and 100 mM) was studied. The 3D printed hydrogels were freeze-dried to produce aerogels which were tested for water absorption. Scanning Electronic Microscopy (SEM) pictures demonstrated that the higher the concentration of the cross-linker the higher the definition of the printed tracks. CNF-based aerogels showed a remarkable water absorption capability. Although the incorporation of alginate and the cross-linking with CaCl led to shrinkage of the 3D printed constructs, the approach yielded suitable porous structures for water and moisture absorption. It is concluded that the 3D printed biocomposite structures developed in this study have characteristics that are promising for wound dressings devices.
2,2,6,6-四甲基哌啶-1-氧基（TEMPO）氧化纤维素纳米原纤维（CNF）被用作具有伤口敷料潜力的多孔结构三维（3D）打印的墨水。将藻酸盐（10%、20%、30%和40%重量）加入配方中，以促进与氯化钙（CaCl）的离子交联。研究了两种不同浓度的CaCl（50和100 mM）的效果。将3D打印水凝胶冷冻干燥以制备气凝胶，并对其吸水性进行测试。扫描电子显微镜（SEM）图片表明，交联剂浓度越高，打印轨迹的清晰度越高。基于CNF的气凝胶显示出显著的吸水能力。尽管加入藻酸盐并与CaCl交联导致3D打印结构收缩，但该方法产生了适合吸水和吸湿的多孔结构。得出的结论是，本研究中开发的3D打印生物复合结构具有有望用于伤口敷料装置的特性。
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