光物理特性分析及以金丝桃素及其模型化合物为代表的植物蒽醌类化合物的抗癌活性。

Department of Chemistry, Biochemistry and Biophysics, University of Veterinary Medicine & Pharmacy, Komenského 73, 041 81 Košice, Slovakia.

Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Kateřinská 1, 121 08 Prague, Czech Republic.

Molecules. 2020 Dec 1;25(23):5666. doi: 10.3390/molecules25235666.

Photosensitive compounds found in herbs have been reported in recent years as having a variety of interesting medicinal and biological activities. In this review, we focus on photosensitizers such as hypericin and its model compounds emodin, quinizarin, and danthron, which have antiviral, antifungal, antineoplastic, and antitumor effects. They can be utilized as potential agents in photodynamic therapy, especially in photodynamic therapy (PDT) for cancer. We aimed to give a comprehensive summary of the physical and chemical properties of these interesting molecules, emphasizing their mechanism of action in relation to their different interactions with biomacromolecules, specifically with DNA.

近年来，人们发现草药中的光敏化合物具有多种有趣的药用和生物活性。在这篇综述中，我们重点介绍了金丝桃素及其模型化合物大黄素、醌茜素和丹蒽酮等光敏剂，它们具有抗病毒、抗真菌、抗肿瘤和抗癌作用。它们可用作光动力疗法的潜在药物，特别是在癌症的光动力疗法（PDT）中。我们旨在全面总结这些有趣分子的物理化学性质，强调它们的作用机制与其与生物大分子（特别是 DNA）的不同相互作用有关。