Hua Yunqi, Tian Xiaoling, Zhang Xinyi, Song Ge, Liu Yubo, Zhao Ye, Gao Yuqian, Yin Fangrui
Department of Medical Oncology, Baotou Cancer Hospital, Baotou, China.
Department of Graduate School, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
Front Pharmacol. 2024 Sep 19;15:1476228. doi: 10.3389/fphar.2024.1476228. eCollection 2024.
Photodynamic Therapy (PDT), as a minimally invasive treatment method, has demonstrated its distinct advantages in the management of skin malignant tumors. This article examines the current application status of PDT, assesses its successful cases and challenges in clinical treatment, and anticipates its future development trends. PDT utilizes photosensitizers to interact with light of specific wavelengths to generate reactive oxygen species that selectively eradicate cancer cells. Despite PDT's exceptional performance in enhancing patients' quality of life and prognosis, the limitation of treatment depth and the side effects of photosensitizers remain unresolved issues. With the advancement of novel photosensitizers and innovative treatment technology, the application prospects of PDT are increasingly expansive. This article delves into the mechanism of PDT, its application in various skin malignancies, its advantages and limitations, and envisions its future development. We believe that through continuous technological enhancements and integration with other treatment technologies, PDT has the potential to assume a more pivotal role in the treatment of skin malignancies.
光动力疗法（PDT）作为一种微创治疗方法，在皮肤恶性肿瘤的治疗中已展现出其独特优势。本文探讨了PDT的当前应用状况，评估了其在临床治疗中的成功案例及挑战，并展望了其未来发展趋势。PDT利用光敏剂与特定波长的光相互作用，产生活性氧物质以选择性地根除癌细胞。尽管PDT在提高患者生活质量和预后方面表现卓越，但治疗深度的局限性和光敏剂的副作用仍是尚未解决的问题。随着新型光敏剂和创新治疗技术的进步，PDT的应用前景日益广阔。本文深入研究了PDT的作用机制、其在各种皮肤恶性肿瘤中的应用、其优势与局限性，并展望了其未来发展。我们相信，通过持续的技术改进以及与其他治疗技术的整合，PDT在皮肤恶性肿瘤治疗中有可能发挥更关键的作用。
