CIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain (I.L., M.C., A.-J.A., E.O., A.S.-V.).
IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain (I.L., A.S.-V.).
Stroke. 2021 Jan;52(2):703-706. doi: 10.1161/STROKEAHA.120.030477. Epub 2020 Dec 4.
The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomatic carotid artery disease.
We included patients with symptomatic (n=22) and asymptomatic (n=23) carotid artery disease. We determined all-C18:1 trans, linoleic acid (LA, C18:2n6), alpha-linolenic acid (C18:3n3), and the omega-3 index (sum of eicosapentaenoic [C20:5n3] and docosahexaenoic [C22:6n3] acids) in both red blood cells and carotid plaque phospholipids by gas-chromatography.
In a multivariate logistic regression analysis, we only observed a significant association for LA, whose red blood cell status was inversely related to symptomatic carotid artery disease (odds ratio, 0.116 [95% CI, 0.022-0.607], =0.011, for each 1-SD increase). A similar result was observed for LA in carotid plaque phospholipids.
Cell membrane enrichment in LA, which reflects its intake, was inversely related to symptomatic carotid disease. This increases evidence supporting a favorable role of dietary LA in vascular health.
红细胞脂肪酸组成客观反映了几种脂肪酸的长期饮食摄入情况。在接受颈动脉内膜切除术的患者中，我们探讨了红细胞中选定脂肪酸的状态是否与症状性颈动脉疾病有关。
我们纳入了有症状（n=22）和无症状（n=23）颈动脉疾病的患者。我们通过气相色谱法测定了红细胞和颈动脉斑块磷脂中的全 C18:1 反式、亚油酸（LA，C18:2n6）、α-亚麻酸（C18:3n3）和 ω-3 指数（二十碳五烯酸[C20:5n3]和二十二碳六烯酸[C22:6n3]的总和）。
在多变量逻辑回归分析中，我们仅观察到 LA 呈显著相关性，其红细胞状态与症状性颈动脉疾病呈负相关（比值比，0.116[95%置信区间，0.022-0.607]，=0.011，每增加 1-SD）。颈动脉斑块磷脂中的 LA 也观察到了类似的结果。
细胞膜中 LA 的富集反映了其摄入情况，与症状性颈动脉疾病呈负相关。这增加了支持饮食中 LA 对血管健康有益作用的证据。
