All authors are affiliated with the Stein Eye Institute, University of California, Los Angeles, California.
Dermatol Surg. 2021 Feb 1;47(2):235-237. doi: 10.1097/DSS.0000000000002869.
Intra-arterial injection of fillers can lead to occlusion of the ophthalmic artery or its branches supplying the retina or the optic nerve. The mechanism through which this occurs is incompletely understood. We investigated the possibility of generating microparticles after injecting commercially available fillers into a flowing system in vitro.
Three hyaluronic acid fillers and one calcium hydroxylapatite filler were injected into an artificial saline flow system mimicking arterial systolic blood pressure and corresponding to the diameter of the facial artery. All the saline at the end of the tube was collected, centrifuged, and inspected for filler particles.
After injection into the system, all fillers immediately disintegrated into small particles that were carried downstream with the flow of the saline. The saline at the end of the tube contained collections of filler.
Hyaluronic acid and hydroxylapatite fillers break up into small particles immediately after injection into a flowing system, generating emboli rather than a column of filler. The results of this study lead us to hypothesize another potential mechanism leading to filler-related blindness.
动脉内注射填充物可能导致供应视网膜或视神经的眼动脉或其分支阻塞。其发生的机制尚不完全清楚。我们研究了将市售填充物注入体外流动系统后生成微粒的可能性。
将三种透明质酸填充物和一种羟基磷灰石填充物注入模仿动脉收缩压并与面动脉直径相对应的人工生理盐水流动系统中。收集管末端的所有生理盐水，离心后检查填充物颗粒。
注入系统后，所有填充物立即分解成小颗粒，随生理盐水的流动被携带到下游。管末端的盐水中含有填充物的聚集物。
透明质酸和羟基磷灰石填充物在注入流动系统后立即分解成小颗粒，形成栓子而不是填充物柱。本研究的结果使我们假设另一种潜在的导致与填充物相关的失明的机制。
