Saadat Payam, Faramarzi Mahbobeh, Salimkhani Farnaz, Khafri Soraya
Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Oman Med J. 2020 Nov 30;35(6):e205. doi: 10.5001/omj.2020.91. eCollection 2020 Nov.
Psychiatric disorders in patients with Parkinson's disease (PD) and their caregivers play an important role in patients' treatment and follow-up. Our study aimed to examine the prevalence of psychiatric symptoms among patients with PD and their caregivers, demographic risk factors, and the influence of severity and manifestations of PD on psychiatric distress.
We included 125 patients with PD and 125 of their primary caregivers in this descriptive cross-sectional study. The severity of PD was evaluated according to the Hoehn and Yahr severity scale from the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale. PD patients and their caregivers completed the Symptom Checklist-25 to determine the presence of psychiatric distress. Also, demographic factors, including age, high level of education, occupation, residence, and cigarette smoking, were assessed in the PD patients and their caregivers.
The prevalence of psychiatric distress was 47.2% for PD patients and 18.4% for caregivers. Female sex, city residency, and medical disease were risk factors for more psychiatric symptoms in PD patients. Also, the female sex, single status, living in a village, and having a medical disease were risk factors for greater psychiatric symptoms in caregivers. PD patients in more advanced stages of disease suffered significantly from psychiatric distress, somatization, anxiety, interpersonal sensitivity, obsessive-compulsive disorder, and phobia compared to the lower severity of disease. PD patients with manifestation of postural instability showed a higher score of somatization, phobia, and psychiatric distress as compared with tremor, hypokinesia, and rigidity.
Progression of PD influenced the psychiatric symptoms of both patients and their caregivers. A higher stage of PD is associated with higher scores of psychiatric distress, phobia, and somatization in the patients and their caregivers.
帕金森病（PD）患者及其照料者的精神障碍在患者的治疗及随访中起着重要作用。我们的研究旨在调查PD患者及其照料者中精神症状的患病率、人口统计学风险因素，以及PD的严重程度和表现形式对精神痛苦的影响。
在这项描述性横断面研究中，我们纳入了125例PD患者及其125名主要照料者。根据运动障碍协会赞助修订的统一帕金森病评定量表中的Hoehn和Yahr严重程度量表评估PD的严重程度。PD患者及其照料者完成症状自评量表-25以确定是否存在精神痛苦。此外，还评估了PD患者及其照料者的人口统计学因素，包括年龄、高学历、职业、居住情况和吸烟状况。
PD患者中精神痛苦的患病率为47.2%，照料者为18.4%。女性、城市居住以及患有内科疾病是PD患者出现更多精神症状的风险因素。此外，女性、单身状态、居住在农村以及患有内科疾病是照料者出现更多精神症状的风险因素。与疾病严重程度较低的患者相比，处于疾病更晚期的PD患者在精神痛苦、躯体化、焦虑、人际敏感、强迫症和恐惧症方面的症状更为显著。与震颤、运动迟缓及强直表现的PD患者相比，有姿势不稳表现的PD患者在躯体化、恐惧症及精神痛苦方面得分更高。
PD的进展影响了患者及其照料者的精神症状。更高阶段的PD与患者及其照料者在精神痛苦、恐惧症及躯体化方面的更高得分相关。
