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Transdermal iontophoretic delivery of therapeutic peptides/proteins. I: Insulin.

作者信息

Chien Y W, Siddiqui O, Sun Y, Shi W M, Liu J C

机构信息

Controlled Drug-Delivery Research Center Rutgers, State University of New Jersey, College of Pharmacy, Piscataway 08855-0789.

出版信息

Ann N Y Acad Sci. 1987;507:32-51. doi: 10.1111/j.1749-6632.1987.tb45790.x.

DOI:10.1111/j.1749-6632.1987.tb45790.x
PMID:3327418
Abstract
摘要

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Transdermal iontophoretic delivery of therapeutic peptides/proteins. I: Insulin.
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Transdermal iontophoresis of insulin: III. Influence of electronic parameters.胰岛素的经皮离子电渗疗法：III. 电学参数的影响。
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Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis.采用脂质体和离子导入相结合的方法实现无创性和持久性经毛囊药物传递系统。
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引用本文的文献

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Can breakthroughs in dermal and transdermal macromolecule delivery surmount existing barriers and revolutionize future therapeutics?皮肤和透皮大分子递送方面的突破能否克服现有障碍并彻底改变未来的治疗方法？
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Advances in transdermal insulin delivery.经皮胰岛素传递的进展。
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Non-invasive delivery strategies for biologics.生物制剂的非侵入性递送策略。
Nat Rev Drug Discov. 2019 Jan;18(1):19-40. doi: 10.1038/nrd.2018.183. Epub 2018 Nov 30.
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The effect of alternating current iontophoresis on rats with the chronic constriction injury to the infraorbital nerve.交流电离子导入对眶下神经慢性压迫损伤大鼠的影响。
Int J Dent. 2012;2012:405292. doi: 10.1155/2012/405292. Epub 2012 May 23.
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Simultaneous transdermal extraction of glucose and lactate from human subjects by reverse iontophoresis.通过反向离子电渗法同时从人体受试者中经皮提取葡萄糖和乳酸。
Int J Nanomedicine. 2008;3(2):211-23. doi: 10.2147/ijn.s1728.
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Novel drug delivery systems for insulin: clinical potential for use in the elderly.胰岛素的新型给药系统：在老年人中的临床应用潜力。
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Role of appendages in skin resistance and iontophoretic peptide flux: human versus snake skin.附属器在皮肤电阻和离子导入肽通量中的作用：人类皮肤与蛇皮的比较
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Transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH): effect of repeated administration.
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Iontophoresis of a model peptide across human skin in vitro: effects of iontophoresis protocol, pH, and ionic strength on peptide flux and skin impedance.
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Study of the mechanisms of flux enhancement through hairless mouse skin by pulsed DC iontophoresis.通过脉冲直流电离子导入法增强无毛小鼠皮肤通量机制的研究。
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