Pak J Biol Sci. 2020 Jan;23(11):1431-1435. doi: 10.3923/pjbs.2020.1431.1435.
Lower Urinary Tract Symptoms (LUTS) and Benign Prostatic Hyperplasia (BPH) are progressive ailments resulting from androgenic imbalances and aging that can lead to serious long term complications. Objective of this study was to determine the relationship between prostate-specific antigens and testosterone hormone levels in patients with BPH before transurethral surgery.
This case control study was done on 112 serum samples collected from two secondary care centres in Khartoum, Sudan. Collected serum samples were analyzed by ELISA and fluorescence enzymes immunoassay to measure testosterone, total PSA level and free PSA levels, respectively.
Out of 112 patients, 56 BPH diagnosed patients were included in the study with mean age 67.10±7.90 years. Total PSA (T. PSA) levels were higher in patients (14.1±10.6 ng mL-1) than the control group (2.21±1.01 ng mL-1). Total 52% of patients had total PSA level in the gray zone (4-10 ng mL-1) and 33% had total PSA more than 10 ng mL-1. Testosterone levels were low in patients 3.97±2.84 ng mL-1 when compared to the control group 4.95±0.59 ng mL-1.
The present study revealed that, there was a strong association between T. PSA level and testosterone hormone in BPH patients, which suggested that monitoring of testosterone level is useful in patients with prostate enlargement.
下尿路症状（LUTS）和良性前列腺增生（BPH）是由雄激素失衡和衰老引起的进行性疾病，可导致严重的长期并发症。本研究的目的是在经尿道前列腺切除术之前确定 BPH 患者前列腺特异性抗原（PSA）与睾丸激素水平之间的关系。
这项病例对照研究是在苏丹喀土穆的两个二级保健中心采集的 112 份血清样本上进行的。收集的血清样本通过 ELISA 和荧光酶免疫测定法进行分析，以分别测量睾丸激素、总 PSA 水平和游离 PSA 水平。
在 112 名患者中，有 56 名 BPH 患者被纳入研究，平均年龄为 67.10±7.90 岁。患者的总 PSA（T. PSA）水平高于对照组（14.1±10.6ngmL-1）（2.21±1.01ngmL-1）。总共有 52%的患者总 PSA 处于灰色区域（4-10ngmL-1），33%的患者总 PSA 超过 10ngmL-1。与对照组（4.95±0.59ngmL-1）相比，患者的睾丸激素水平较低，为 3.97±2.84ngmL-1。
本研究表明，在 BPH 患者中，T. PSA 水平与睾丸激素之间存在很强的关联，这表明监测睾丸激素水平对前列腺增大的患者有用。
