Pak J Biol Sci. 2020 Jan;23(12):1650-1658. doi: 10.3923/pjbs.2020.1650.1658.
Numerous experimental studies have shown various pharmacological activities including geraniol's cancer prevention agent and antioxidant capacity. The goal of this investigation is to mark the prospective defensive role of geraniol in rat's carbon tetrachloride (CCl4) instigated in liver fibrosis.
Liver fibrosis was prompted by subcutaneous injections of CCl4, twice week by week and for about a month. Simultaneously, geraniol (200 mg kg-1) was orally regulated every day. Post-Hoc-Test were carried out where p<0.05 has been established as a significant value.
The biochemical results showed that geraniol reduced liver damage just as manifestations of liver fibrosis. The administration of geraniol diminished the CCl4-initiated the elevation in serum aminotransferase activities and alkaline phosphatase activity. Geraniol diminished the levels of TNF-α, NO and myeloperoxidase activity which were prompted by the CCl4 treatment. The rise of serum hyaluronidase activity and hepatic hydroxyproline content was also curtailed by geraniol treatment. Besides, geraniol fundamentally declined hepatic malondialdehyde (MDA) formation and increased reduced glutathione (GSH) in CCl4-treated rats. Geraniol has also increased the activity of hepatic antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione peroxidase (GPx) in the rats treated with CCl4. Finally, the histological analysis of the liver bolstered the biochemical results.
Our study has demonstrated that geraniol has a hepatoprotective upshot on liver fibrosis caused by CCl4, supposedly due to its free radical scavenging, antioxidant and anti-inflammatory characteristics.
许多实验研究表明，香叶醇具有多种药理学活性，包括抗癌和抗氧化能力。本研究旨在探讨香叶醇对大鼠四氯化碳（CCl4）诱导肝纤维化的潜在保护作用。
通过皮下注射 CCl4，每周两次，持续约一个月，诱导肝纤维化。同时，每天口服香叶醇（200mg/kg）。进行事后检验，p<0.05 为显著值。
生化结果表明，香叶醇减轻了肝损伤和肝纤维化的表现。香叶醇降低了 CCl4 引起的血清转氨酶和碱性磷酸酶活性升高。香叶醇降低了 CCl4 诱导的 TNF-α、NO 和髓过氧化物酶活性的升高。香叶醇还降低了血清透明质酸酶活性和肝羟脯氨酸含量的升高。此外，香叶醇从根本上降低了 CCl4 处理大鼠肝丙二醛（MDA）的形成，增加了还原型谷胱甘肽（GSH）。香叶醇还增加了 CCl4 处理大鼠肝抗氧化酶的活性，如超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽还原酶（GR）、谷胱甘肽-S-转移酶（GST）和谷胱甘肽过氧化物酶（GPx）。最后，肝组织学分析支持了生化结果。
本研究表明，香叶醇对 CCl4 诱导的肝纤维化具有肝保护作用，可能与其自由基清除、抗氧化和抗炎特性有关。
