Endocrine Department, Yan'an Hospital of Kunming City, Kunming, P.R. China.
Eur Rev Med Pharmacol Sci. 2020 Nov;24(22):11707-11715. doi: 10.26355/eurrev_202011_23816.
The aim of the study was to investigate the relationship between ER stress and liver function, insulin resistance and vascular endothelial function in patients with non-alcoholic fatty liver disease.
A total of 95 patients with non-alcoholic fatty liver disease were selected. They were admitted to our hospital from November 2016 to January 2019. A total of 90 cases of obese patients without fatty liver were selected as control group during the same period. The levels of ER stress marker protein were compared between the two groups, and the relationship between ER stress and liver function, insulin resistance, and vascular endothelial function was analyzed.
The protein level of ER stress markers in the test group was significantly higher than that in the control group (p<0.05). The liver function index and insulin resistance level were significantly higher than those in the control group (p<0.05). The level of vascular endothelial function was significantly lower than that of the control group (p<0.05). Pearson correlation analysis showed that ER stress marker protein was positively correlated with liver function and insulin resistance (p<0.05), while ER marker protein was negatively correlated with vascular endothelial function (p<0.05).
Liver function and insulin resistance are closely related to ER stress in patients with non-alcoholic fatty liver disease. Insulin resistance is one of the factors inducing and aggravating endothelial dysfunction.
研究旨在探讨非酒精性脂肪肝患者内质网应激与肝功能、胰岛素抵抗和血管内皮功能之间的关系。
选取 2016 年 11 月至 2019 年 1 月我院收治的非酒精性脂肪肝患者 95 例为观察组，选取同期肥胖但无脂肪肝患者 90 例为对照组。比较两组患者内质网应激标志物蛋白水平，并分析内质网应激与肝功能、胰岛素抵抗及血管内皮功能的关系。
观察组内质网应激标志物蛋白水平显著高于对照组（p<0.05），肝功能指标及胰岛素抵抗水平均显著高于对照组（p<0.05），血管内皮功能水平显著低于对照组（p<0.05）。Pearson 相关性分析显示，内质网应激标志物蛋白与肝功能及胰岛素抵抗呈正相关（p<0.05），而与血管内皮功能呈负相关（p<0.05）。
非酒精性脂肪肝患者肝功能和胰岛素抵抗与内质网应激密切相关，胰岛素抵抗是导致并加重内皮功能障碍的因素之一。
