Department of Chemistry, Rice University, Houston, TX 77005, USA; Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Republic of Korea; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea.
College of Pharmacy, Korea University, Sejong 30019, Republic of Korea.
Nucl Med Biol. 2021 Feb;93:22-36. doi: 10.1016/j.nucmedbio.2020.11.004. Epub 2020 Nov 21.
Dual Positron emission tomography (PET)/optical imaging techniques have captured scientific interest for clinical applications due to their potential as an effective tool for visualizing in vivo information such as disease processes. 4,4'-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye has been considered an ideal platform strategy to achieve dual PET/optical imaging due to its photochemical nature and chemical structure. Various radiofluorination methods to prepare [F]BODIPY dye have been developed and established, ranging from nucleophilic substitution reactions to isotope exchange reactions. In addition, F-labelled BODIPY dyes for biologically important targets have been used for in vivo and ex vivo studies. These studies proved the practicality of [F]BODIPY dyes as a hybrid PET/optical imaging probe. In this review, recent advances in the synthesis and biological evaluation of F-labelled BODIPY dyes are described.
双正电子发射断层扫描（PET）/光学成像技术因其作为可视化体内信息（如疾病过程）的有效工具的潜力而引起了临床应用的科学兴趣。4,4'-二氟-4-硼-3a,4a-二氮杂-s-茚（BODIPY）染料因其光化学性质和化学结构而被认为是实现双 PET/光学成像的理想平台策略。已经开发并建立了各种放射性氟标记方法来制备[F]BODIPY 染料，范围从亲核取代反应到同位素交换反应。此外，用于生物重要靶标的 F 标记的 BODIPY 染料已用于体内和体外研究。这些研究证明了[F]BODIPY 染料作为混合 PET/光学成像探针的实用性。在这篇综述中，描述了 F 标记的 BODIPY 染料的合成和生物学评价的最新进展。
