Carlin W V, Lesser T H, John D G, Fielder C, Carrick D G, Thomas P L, Hill S
Department of Otolaryngology, University Hospital of Wales, Cardiff.
Clin Otolaryngol Allied Sci. 1987 Dec;12(6):441-6. doi: 10.1111/j.1365-2273.1987.tb00230.x.
This paper reports a multicentre, controlled, blind, prospective, randomized study into the use of prophylactic systemic antibiotics in myringoplasty surgery. Seventy-one individuals were clinically and bacteriologically assessed both preoperatively, and for a period of 8 weeks postoperatively. The results showed that antibiotic prophylaxis did not eradicate bacterial pathogens already present in preoperative ears, nor did it prevent their development during the postoperative period. The observation that an ear was wet or dry gave no indication of the actual presence or absence of pathogenic organisms.
本文报告了一项关于在鼓膜成形术手术中使用预防性全身抗生素的多中心、对照、盲法、前瞻性、随机研究。对71名个体在术前以及术后8周进行了临床和细菌学评估。结果表明，预防性使用抗生素并不能根除术前耳部已存在的细菌病原体，也不能预防其在术后阶段的滋生。耳部潮湿或干燥这一观察结果并不能表明是否实际存在致病生物。
