Puentes-Pardo Jose D, Moreno-SanJuan Sara, Carazo Ángel, León Josefa
Research Unit, Instituto de Investigacion Biosanitaria de Granada, ibs.GRANADA, 18012 Granada, Spain.
Department of Pharmacology, Faculty of Pharmacy, University of Granada, 18011 Granada, Spain.
Antioxidants (Basel). 2020 Dec 2;9(12):1214. doi: 10.3390/antiox9121214.
Heme oxygenase 1 (HO-1) is the rate-limiting enzyme of heme oxidative degradation, generating carbon monoxide (CO), free iron, and biliverdin. HO-1, a stress inducible enzyme, is considered as an anti-oxidative and cytoprotective agent. As many studies suggest, HO-1 is highly expressed in the gastrointestinal tract where it is involved in the response to inflammatory processes, which may lead to several diseases such as pancreatitis, diabetes, fatty liver disease, inflammatory bowel disease, and cancer. In this review, we highlight the pivotal role of HO-1 and its downstream effectors in the development of disorders and their beneficial effects on the maintenance of the gastrointestinal tract health. We also examine clinical trials involving the therapeutic targets derived from HO-1 system for the most common diseases of the digestive system.
血红素加氧酶1（HO-1）是血红素氧化降解的限速酶，可生成一氧化碳（CO）、游离铁和胆绿素。HO-1是一种应激诱导酶，被认为是一种抗氧化和细胞保护剂。正如许多研究表明的那样，HO-1在胃肠道中高度表达，它参与炎症过程的反应，这可能导致多种疾病，如胰腺炎、糖尿病、脂肪肝疾病、炎症性肠病和癌症。在这篇综述中，我们强调了HO-1及其下游效应器在疾病发展中的关键作用以及它们对维持胃肠道健康的有益作用。我们还研究了涉及源自HO-1系统的治疗靶点用于消化系统最常见疾病的临床试验。
