Department of Biology, Laurentian University, 935 Ramsey Lake Rd., Sudbury, ON P3E 2C6, Canada.
Toxins (Basel). 2020 Dec 2;12(12):760. doi: 10.3390/toxins12120760.
Enterotoxigenic (ETEC) produces the heat-stable enterotoxin b (STb), which is responsible for secretory diarrhea in humans and animals. This toxin is secreted within the intestinal lumen of animals and humans following ETEC colonization, becoming active on enterocytes and altering fluid homeostasis. Several studies have outlined the nature of this toxin and its effects on gut health and the integrity of the intestinal epithelium. This review summarizes the mechanisms of how STb alters the gastrointestinal tract. These include the manipulation of mucosal tight junction protein integrity, the formation of enterocyte cellular pores and toxin internalization and the stimulation of programmed cell death. We conclude with insights into the potential link between STb intoxication and altered gut hormone regulation, and downstream physiology.
肠产毒性大肠杆菌（ETEC）产生热稳定肠毒素 b（STb），该毒素负责人类和动物的分泌性腹泻。这种毒素在 ETEC 定植后在动物和人类的肠腔中分泌，在肠细胞上变得活跃，并改变液体动态平衡。有几项研究概述了这种毒素的性质及其对肠道健康和肠上皮完整性的影响。本综述总结了 STb 改变胃肠道的机制。这些包括对粘膜紧密连接蛋白完整性的操纵、肠细胞细胞孔的形成和毒素内化以及程序性细胞死亡的刺激。我们最后深入了解了 STb 中毒与改变肠道激素调节和下游生理学之间的潜在联系。
