Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, 200031, China.
NHC Key Laboratory of myopia (Fudan University), Shanghai, China.
BMC Ophthalmol. 2020 Dec 4;20(1):476. doi: 10.1186/s12886-020-01720-6.
To report undescribed characteristics of patients with bilateral diffuse uveal melanocytic proliferation (BDUMP) on ultrasound biomicroscopy (UBM) and high-frequency B-scan ultrasonography.
Two of four participants presented with worsening bilateral vision after previously diagnosed primary pulmonary or ovarian carcinoma. The other two patients were diagnosed with lung carcinoma after presentation with BDUMP. All patients had ciliary body nevi-like lesion in combination with iris or ciliary body cysts, and uveal thickening on UBM. Focally elevated choroidal nevi-like lesion and exudative retinal detachment with choroidal thickening were detected with B-scan ultrasonography.
Our case series demonstrates the uveal characteristics of patients with BDUMP based on high-frequency B-scan ultrasonography and UBM. Ultrasonographic findings are crucial in the diagnosis of BDUMP because it is occult in nature.
报告在超声生物显微镜（UBM）和高频 B 型扫描超声检查中双侧弥漫性葡萄膜黑色素细胞增生（BDUMP）患者的未描述特征。
4 名参与者中有 2 名在先前诊断为原发性肺或卵巢癌后出现双侧视力恶化。另外两名患者在出现 BDUMP 后被诊断为肺癌。所有患者均存在睫状体痣样病变，伴有虹膜或睫状体囊肿，UBM 显示葡萄膜增厚。高频 B 型扫描超声检查发现局灶性隆起的脉络膜痣样病变和伴有脉络膜增厚的渗出性视网膜脱离。
本病例系列基于高频 B 型扫描超声和 UBM 展示了 BDUMP 患者的葡萄膜特征。由于 BDUMP 本质上是隐匿性的，因此超声检查结果对其诊断至关重要。
